Although they are about the same size as coronavirus particles and one-thousandth the size of human hair, the newly designed nanoparticles developed by scientists at the University of South Australia weigh much more when it comes to treating drug-resistant fungi. It exceeds. Infection.
Created in collaboration with the University of Monash, a new nanobiotechnology (called a “micelle”) has the ability to combat one of the most invasive and notorious resistant fungal infections, the Candida albicans. Aqueous solution. Both of them attract and repel liquids, making them particularly suitable for drug delivery.
This is a timely discovery, especially given the significant increase in dangerous fungal infections in hospitals in countries affected by COVID-19.
Candida albicans is an opportunistic pathogenic yeast that is extremely dangerous to people with a weakened immune system, especially those in hospitals. Candida albicans, found on many surfaces, is notorious for its resistance to antifungal drugs. It is the most common cause of fungal infections worldwide and can cause serious infections that can affect the blood, heart, brain, eyes, bones, and other parts of the body. there is.
Professor Clive Prestidge, a senior researcher at UniSA, said new polymer-based micelles could revolutionize current antifungal drugs.
“Many fungal biofilms are resistant to modern antifungal drugs, making invasive fungal infections particularly difficult to manage and treat,” says Professor Prestige.
“Fungal biofilms are surface-loving microorganisms that propagate in implantable devices such as catheters, prostheses, and heart valves, making the presence of these devices a major risk factor for infection.
“In places like India, where about 40,000 new COVID-19 infections occur daily, healthcare professionals are not only fighting COVID-19, but because of the significant expansion of hospital resources. We also deal with complacency and fatigue.
“Unfortunately, infection control practices have deteriorated and patients have Mechanical ventilation There is an increased risk of developing a bacterial or fungal infection.
“Fungal biofilms tend to be the seeds of recurrent infections, so it is especially important now to find a way to break and defeat the infection cycle.
“Our study identifies and develops smart micelles capable of degrading single and multiple biofilms and significantly inhibiting the growth of one of the most virulent fungal species, Candida albicans. Did.
“We estimate that the new micelles can improve the effectiveness of antifungal drugs by a factor of 100 and save the lives of millions of people around the world.”
Collaborator Dr. Nicky Thomas says the new micelles will bring breakthroughs in the treatment of invasive fungal infections.
“These micelles have the unique ability to solubilize and capture a variety of important antifungal agents, significantly improving their performance and effectiveness.”
“This is the first time a polymer-based micelle has been created with a unique function to prevent fungi. Biofilm Formation.
“Our results already show that new micelles remove up to 70 percent. infection, This could be a true game changer for treating fungal diseases. ”
Yassamin N. Albayaty et al, polymeric micelles with antitoxic activity against Candida albicans in single and dual biofilms, Drug delivery and translation studies (2021). DOI: 10.1007 / s13346-021-00943-4
Yassamin N. Albayaty et al, pH-responsive copolymer micelles for enhancing the effectiveness of itraconazole on Candida albicans biofilms, Journal of Materials Chemistry B (2020). DOI: 10.1039 / C9TB02586C
University of South Australia
Quote: Fighting fungal infections: A big leap forward in smart nanotechnology (August 16, 2021) from https: //phys.org/news/2021-08-fungal-infections-giant-smart-nanotech.html 2021 Acquired on August 16, 2014
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A big leap in smart nanotechnology
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