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A more effective booster than the mRNA vaccine for ChAdOx1nCoV-19

(HealthDay)-The use of heterologous ChAdOx1 nCoV-19 and mRNA prime boost vaccinations is more effective than allogeneic ChAdOx1 nCoV-19 / ChAdOx1 nCoV-19 prime boost vaccinations. Lancet Regional Health: Europe..

Peter Nordström, MD, Ph.D. from Umeå University, Sweden. We investigated the efficacy of heterologous prime boost COVID-19 vaccination in Swedish individuals who received two doses of COVID-19. vaccination The study cohort included 94,569 people who received the heterologous ChAdOx1 nCoV-19 / BNT162b2 prime boost vaccination, 16,402 people who received the ChAdOx1 nCoV-19 / mRNA-1273 prime boost vaccination, and 430,100 people who received the allogeneic ChAdOx1. It was. nCoV-19 / ChAdOx1 nCoV-19 Prime Boost Vaccination. In addition, 180,716 individuals who were not vaccinated on the date of vaccination of the corresponding cases were selected.

Researchers found that 187 patients on a heterologous vaccine schedule (incidence, 2.0 / 100,000 man-days) and 306 patients in an unvaccinated control group (incidence, 7.1 per 100,000 man-days) were symptomatic during an average follow-up period. COVID-19 infection was confirmed. -Until 76 days. Adjusted vaccine efficacy was 67% and 79% for heterologous ChAdOx1 nCoV-19 / BNT162b2 prime boost vaccination and heterologous ChAdOx1 nCoV-19 / mRNA-1273 prime boost vaccination, respectively. When analyzed in combination, the vaccine efficacy of the heterologous schedule was 68%, significantly higher than 50%. effect It is found in the same species of ChAdOx1nCoV-19 vaccination.

“our study Nordstrom said in a statement that those who received the vector-based vaccine first had a significantly lower risk for those who received the mRNA vaccine than those who received the vector-based vaccine at both doses. Is shown.


The efficacy of the COVID-19 vaccine increases at 3-month dosing intervals


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Quote: A more effective booster for the mRNA vaccine against ChAdOx1 nCoV-19 (2021, October 22) is from https://medicalxpress.com/news/2021-10-mrna-vaccine-effective-booster-chadox1.html Acquired on October 22, 2021

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A more effective booster than the mRNA vaccine for ChAdOx1nCoV-19

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