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A new study identifies possible causes of Alzheimer’s disease

Diagram of the brain of a person with Alzheimer’s disease. Credit: Wikipedia / public domain.

A groundbreaking new study led by Curtin University has uncovered a possible cause of Alzheimer’s disease. This is an important finding that offers potential new prevention and treatment opportunities for Australia’s second most common cause of death.

First-class so published research PLOS Biology Tested in journals and mouse models, blood is a possible cause of Alzheimer’s disease brain Of fat-carrying particles that transport toxic proteins.

Principal Investigator John Mamo, director of the Cartin Health Innovation Institute (CHIRI), said his collaborative group of Australian scientists could lead to Alzheimer’s disease, the most prevalent form of dementia in the world. “The route from to the brain” was identified.

“We previously knew that people with Alzheimer’s disease were characterized by a progressive accumulation of toxic protein deposits in the brain called beta-amyloid, but researchers have found out where amyloid came from. I didn’t know why it was deposited in the brain, “said Professor Mamo.

“Our study shows that these toxic protein deposits that form in the brains of people with Alzheimer’s disease are most likely to leak into the brain from blood fat-carrying particles called lipoproteins. ..

“This” blood-to-brain route “is important. This is because controlling blood levels of lipoprotein-amyloid and preventing it from leaking into the brain opens up potential new treatments to prevent Alzheimer’s disease and delay memory loss. “

Built on previous award-winning studies that showed Beta amyloid Professor Mamo’s team, which uses lipoproteins to make lipoproteins outside the brain, genetically engineered a mouse model to create a human amyloid-only liver that makes lipoproteins, a groundbreaking “blood-to-brain pathway.” I tested.

“As we predicted, this study found that a mouse model that produces lipoproteins-amyloid in the liver causes brain inflammation, accelerating brain cell death and memory loss,” said Mamo. rice field.

“Currently, further research is needed, but the finding is that the abundance of these toxic protein deposits in the blood may specifically target the human diet and lipoprotein amyloid. It shows that the drug may be able to deal with it. “

Warren G. Harding, an adjunct professor at WA Chairman of Alzheimer’s disease, said the findings could have significant global implications for millions of people with Alzheimer’s disease.

“In cooperation with a university like Curtin Pharmaceutical industry It’s important to tackle this catastrophic disease. “

“In Australia, about 250 people are diagnosed with dementia every day, and 500,000 Australians who already have dementia are astounding. Without the breakthroughs of Professor Mamo’s team, Australia The number of people is estimated. By 2058, there will be more than one million people with dementia, which will have a significant impact on families, caregivers and communities. “

Previous work in this area by Professor Mamo and his research team received the NHMRC-Marshall and Warren Award for the most innovative and potentially transformative work.

The team is currently conducting clinical trials. Alzheimer’s Disease Probucol-Clinical TrialsThis is based on the previous finding that historic cardiovascular drugs reduce lipoprotein-amyloid production and support the cognitive abilities of mice.

The full text of the treatise is entitled “Proteins from the liver can cause Alzheimer’s disease in the brain.”


Proteins from the liver can cause Alzheimer’s disease in the brain


For more information:
Proteins from the liver can cause Alzheimer’s disease in the brain, PLOS Biology (2021).

Provided by
Curtin University

Quote: A new study found a possible cause of Alzheimer’s disease (September 15, 2021) obtained from https://medicalxpress.com/news/2021-09-alzheimer-disease.html on September 15, 2021. Identified

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A new study identifies possible causes of Alzheimer’s disease

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