Researchers at the University at Buffalo, New York, have developed new processes for creating 3D artificial tissue, experimental drug tests, and advances that can improve the quality of artificial organs.
Is explained in Advanced science, This method is based on compression buckling. This is a structural engineering principle that explains why figures stick out from the pages of a children’s pop-up book.
“When you look at a new page, you create power. When this power pulls on the figure, it opens the creases and pops out,” said research co-author Dr. Ruogang Zhao. .. , Associate Professor of Biomedical Engineering. “This study shows that the same principles can be applied to artificially designed ones. Organization.. “
In a series of experiments, researchers used the compression buckling method to produce a variety of three-dimensional polymer structures. These include not only simple shapes such as boxes and pyramids, but also Sound wave An eight-legged design similar to an octopus.
To demonstrate the usefulness of this method in tissue engineering, the team created a bone sol-like structure. Bone sol is the basic building block of bone tissue and is characterized by the sparse distribution of bone cells in the scaffolding of mineral bone. Each bone cell is located in a small cavity known as a fissure, and different bone cells are connected via canals, which are small channels of bone scaffolding.
The results are important, Zhao says, because most tissue engineers rely on two-dimensional tissue fabrication methods to create very thin tissues that do not represent the volume of human tissue. The planar nature of these tissue models limits their application to disease modeling and drug testing, he says.
Compressed buckling can be used to quickly transform 2D tissue into 3D tissue of considerable thickness, allowing researchers to create more realistic tissue and open up new possibilities for tissue engineering and regenerative medicine. can do. It can also perform better than other 3D techniques. Human tissue engineeringIn terms of manufacturing speed and spatial resolution, such as 3D bioprinting, Zhao says.
Zhaowei Chen et al, Compression Buckling Manufacture of Fine Structures Including 3D Cells, Advanced science (2021). DOI: 10.1002 / advs.202101027
Quote: A new method inspired by the Children’s Pop-up Book for Creating 3D Artificial Tissues (October 15, 2021) is https: //phys.org/news/2021-10-method-kid-pop-up Obtained from -3d on October 15, 2021-artificial.html
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A new way inspired by children’s pop-up books to create 3D artificial tissue
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