The research team at Vanderbilt University Medical Center Neurology Larger hardening of the aorta, the main artery of the human body, is associated with older people with increased Alzheimer’s disease (AD), as reflected in a series of neurochemical indicators measured in cerebrospinal fluid. I have.
“These results have a significant impact on the prevention of Alzheimer’s disease,” said a professor of neurology and founding director of the Vanderbilt Memory and Alzheimer’s Center, who led the study with MD / Ph.D. Elizabeth Moore. Dr. Angela Jefferson said. Under the guidance of Jefferson, a recently PhD student.
“Based on previous studies, we have identified specific pathological pathways in which cardiovascular health is associated with cognitive decline in aging,” Jefferson said. “This study has discovered new associations between larger arteries. rigidity Inflammation, synaptic injury, neurofibrillary tangles, biomarkers of neurodegeneration, all pathological processes present in Alzheimer’s disease.
“As we gain a better understanding of the impact of cardiovascular health on biomarkers for Alzheimer’s disease, we have more potential prevention and treatment options for this devastating and costly disease.”
The new findings are based on a test of 146 patients aged 60-90 years without dementia or neurological disorders. Patients are a subset of participants in the Vanderbild Memory and Aging Project, a Jefferson-led magnifying cohort study focused on uncovering the pathways of injury that accelerate or ameliorate the clinical manifestations of AD.
Although there may not be a single cause of Alzheimer’s disease, various neurochemical indicators may define not only the pathology of the AD core and the final progression of the disease, but also the risk of AD in asymptomatic patients. I have. In previous studies Aortic sclerosis And two of these AD biomarkers-increased amyloid beta and deposition of phosphorylated tau.
New findings from VUMC based on more sensitive measurements of arteriosclerosis, contrary to the first findings of these previous findings, support the second finding and with biomarkers thought to be associated with aortic sclerosis and AD. Identify three new associations between.
In asymptomatic subjects aged 74 years and older, this study found an association between increased aortic sclerosis and increased cerebrospinal fluid concentration for four of the seven AD biomarkers tested. Phosphorylated tau and total tau are considered indicators of neurodegeneration in AD. Neurogranin, which is considered to be an indicator of synaptic dysfunction in AD. And a glycoprotein called YKL-40 is considered to be an indicator of neuroinflammation in AD.
It has long been understood that age-related arteriosclerosis carries the risk of the following events: heart attack Stroke, and more recent studies, have been found to be associated with cognitive impairment, changes in brain structure, and cerebral microvascular disease.A previous study led by Jefferson and colleagues found that increased aortic sclerosis and decreased cardiac output were associated with decreased cardiac output. Cerebral blood flow There is an increased risk of cognitive decline.
“Previously, we have shown that as arteriosclerosis increases, blood flow to the cerebral microcirculation decreases. Cognitive decline“This new study adds evidence of a paradigm shift that vascular risk factors may also contribute to molecular pathology, which is thought to cause core Alzheimer’s disease. disease And associated medical conditions. ”
Elizabeth E Moore et al, Association of Aortic Stiffness with Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration, Neurology (2021). DOI: 10.1212 / WNL.0000000000012257
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Arteriosclerosis associated with Alzheimer’s disease
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