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BAK / MCL1 complex can predict chemotherapeutic drug susceptibility in cancer cells

Possible mechanisms of BAK / MCL1 cell susceptibility to paclitaxel. Credit: Li Yunjian

A research team led by Professor Dai Haiming of the Hefei Institute of Materials Science (HFIPS) at the Chinese Academy of Sciences (CAS) recently announced that the constitutive BAK / MCL1 complex can predict chemotherapeutic susceptibility to ovarian cancer.Results published in Cell death and disease..

Researchers have found that the state of intracellular BAK activation and interaction can predict the susceptibility of blood and lymphoma tumor cells to BH3 analogs. Ovarian cancer As a research subject, we analyzed the relationship between the state of BAK in tumor cells and the susceptibility of tumors to conventional chemotherapy.

The incidence of ovarian cancer ranks third among gynecologic tumors. Ovarian cancer is currently treated with traditional chemotherapeutic agents such as platinum and paclitaxel, but these are not very efficient and antitumor susceptibility predictions are effective for the quality of life and life cycle of patients. Can be improved. Currently, various methods based on genes, in vitro drug screening, and patient-derived xenotransplantation (PDX) models are being applied to predict antineoplastic susceptibility.

In this study, researchers found that the BAK / MCL1 complex Tumor cells You can predict the sensitivity of paclitaxel, MCL1 inhibitors, and combinations thereof. With further research on the PDX model Animal experimentation It also shows the predictive effect of the BAK / MCL1 complex.


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For more information:
Dongyan Liu et al, a constitutive BAK / MCL1 complex, predicts paclitaxel and S63845 susceptibility to ovarian cancer. Cell death and disease (2021). DOI: 10.1038 / s41419-021-04073-0

Provided by
Chinese Academy of Sciences

Quote: BAK / MCL1 complex is a cancer cell obtained on September 15, 2021 from https: //medicalxpress.com/news/2021-09-bakmcl1-complexes-chemotherapy-drugs-sensitivevity.html (9 2021) You can predict the susceptibility of chemotherapeutic drugs (15th of March).

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BAK / MCL1 complex can predict chemotherapeutic drug susceptibility in cancer cells

Source link BAK / MCL1 complex can predict chemotherapeutic drug susceptibility in cancer cells

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