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Black women have a three-fold increased risk of triple-negative breast cancer

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An analysis of approximately 200,000 patients who received mammograms between 2006 and 2015 on three US healthcare systems found heterogeneity of breast cancer risk factors in women of different races, ages, and disease subtypes. It emphasizes the importance of understanding. The study, led by researchers at the University of Pennsylvania’s Perelman School of Medicine, Cancer medicine..

The cohort included 29,822 (15 percent) black women. Cancer research.. Most surprisingly, researchers found that black women had a nearly three-fold increased risk of triple-negative breast cancer and a poor prognosis. Black women are known to be at increased risk for this type of breast cancer, but the magnitude of the risk found in this study is influential given the comprehensive adjustment of breast cancer risk factors in the screened population. was.

In addition, researchers found that triple-negative breast cancer was less likely to be detected by screening and was more likely to be diagnosed with intermittent cancer than other subtypes.Higher breast density was associated with increased risk for all four tumor A more strongly associated subtype between ER / PR + HER2- and TNBC premenopausal women.

In another study, led by the same group, researchers further investigated risk factors for black women. They found that breast cancer was more strongly associated with TNBC than other subtypes, and that obesity was associated with a greater risk of TNBC in this group.The results of those surveys were published in Breast Cancer Research and Treatment..

“Available risk prediction models are about 60 percent accurate for predicting breast cancer risk,” said Dr. Anne Marie McCarthy, assistant professor of epidemiology at Penn. “In our study, Risk factor Throughout these types of breast cancer, better work needs to be done to identify ways to accurately predict the risk of women, especially those of color. ”


Breast density associated with the risk of invasive breast cancer in people over the age of 65


For more information:
Anne-Marie McCarthy et al., Relationship between established risk factors and breast cancer subtypes, Cancer medicine (2021). DOI: 10.1002 / cam4.4158

Tara M. Friebel-Klingner et al, Risk Factors for Breast Cancer Subtypes in Black Women Under Screening Mammography, Breast Cancer Research and Treatment (2021). DOI: 10.1007 / s10549-021-06340-2

Quote: Black women have triple-negative breast cancer acquired on September 20, 2021 from https://medicalxpress.com/news/2021-09-black-women-three-fold-triple-negative (September 20, 2021) The risk of (day) has tripled. .html

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Black women have a three-fold increased risk of triple-negative breast cancer

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