Bubbles reveal oxygen levels

Researchers have developed microbubbles to acoustically detect blood oxygen levels. Credit: Shashank Sirsi

Blood carries biooxygen to muscles and organs through the circulatory system. Acoustic tools can create small bubbles in the blood that change in response to oxygen and indicate oxygen levels.

At the 181st Annual Meeting of the American Acoustic Society from November 29th to December 3rd, Shashank Sirsi of the University of Texas at Dallas will discuss how to measure using circulating microbubbles. air level. The lecture “Hemoglobin Microbubbles for Invivo Blood Oxygen Level Dependent Imaging: Moving Boldly Beyond MRI” will be held on Monday, November 29th.

Microbubbles are less than one-hundredth of a millimeter in diameter and can be created by emulsifying lipids or proteins with gas. The gas filling of microbubbles causes the microbubbles to vibrate and vibrate when ultrasonic waves are applied, scattering energy and producing an acoustic response that can be detected by a clinical ultrasonic scanner. They are routinely used in medical images to increase tissue contrast.

Hemoglobin, protein to give Red blood cells Their distinctive colors form a stable shell around the microbubbles. It then continues to play the typical role of binding and releasing oxygen in the blood.

Shirushi and his team have developed microbubbles for acoustically detecting blood. Oxygen levelBecause the microbubble shell changes due to changes in structural hemoglobin in response to oxygen. The hemoglobin shell is optimized to function in the body’s circulation by continuously reacting to oxygen even after surrounding the bubble.

“When oxygen binds to hemoglobin, there is a structural change in the protein, mechanical nature“Shirushi said. “The mechanical properties of the shell Acoustic response In the case of bubbles, it was hypothesized that different acoustic responses would be seen as the shell became stiffer or more elastic. “

Preliminary results Oxygen concentration The acoustic bubble response highlights the potential use of microbubbles as an oxygen sensor. This function brings many benefits to medical and diagnostic imaging, such as tumor oxygen-deficient areas and evaluation in the brain.

Microbubbles make breast cancer more susceptible to radiation therapy

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Quote: Bubbles reveal oxygen levels (2021, November 29) obtained on November 29, 2021 from https: //

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Bubbles reveal oxygen levels

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