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By interrupting a high-fat, high-calorie diet in a regular “fasting” cycle, mice can lead a longer and healthier life: Studies

Regular repetition of a fast-mimicking diet improved the health and longevity of mice that ate a high-fat diet.Credits: Jonathan Haase / University of Southern California

In a new USC study on the health effects of a low-calorie diet that mimics fasting in the body, researchers found that a regular 5-day dietary cycle in mice counteracts the harmful effects of normal high-fat, high-calorie diets. I found that it looks like. diet.Study published today Natural metabolismWe analyzed the diet, health and longevity of three different groups of mice over a two-year period.

Researchers have shown that a diet that mimics fasting may be used as a “medicine.” A fasting-mimicking diet (FMD) is a low-calorie diet that “fools” the body into a fasting state.

A group of mice ate high calories. High-fat diet (60% of calories come from fat) and became unhealthy and overweight. Mice in the second group ate the same poor diet as the first group for about 4 weeks, then FMD for 5 days, and a normal healthy diet for 2 days.

The authors of the study say that these simple dietary interventions were sufficient for the second group to return to normal levels of cholesterol, blood pressure, and body weight. In particular, mice fed a diet that mimics fasting for five days each month lived as long as the third group of mice that were consistently fed a healthy diet.

In humans, obesity caused by a high-fat, high-calorie diet is a major risk factor for metabolic syndrome, diabetes and cardiovascular disease.

“This study shows that mice can eat a relatively bad diet that is offset by a diet that mimics a five-day fast,” said the director of the National Center for Geriatrics and Gerontology at the USC Leonard Davis School of Gerontology. Senior author of the study, Valter Longo, said. Professor of Biological Sciences, USC Dornife University of Literature, Arts and Sciences. “Our main finding is that intervention in this diet improved the elasticity and function of the heart compared to mice that ate only a high-fat, high-calorie diet.”

The authors of the study state that the FMD cycle appeared to prevent obesity in mice by reducing the accumulation of visceral and subcutaneous fat without causing lean body mass loss. The FMD cycle also appeared to improve heart function and prevent hyperglycemia and high cholesterol.

Researchers have shown that the effect of the FMD cycle on gene expression has shown a role in adipocyte reprogramming in obesity prevention. Specifically, the effects of diet on fat accumulation and heart aging may explain protection from premature death caused by a high-fat, high-calorie diet.

Researchers warn that these results should not be misunderstood. They emphasize that we do not recommend humans to eat high-calorie, high-fat diets that are reduced by regular fasting.

They, however Potential benefitsHow to counteract poor eating habits in this way needs further research Clinical trials.. These strategies may provide potential health benefits to people who are willing or may not be able to change their diet on a daily basis.

The most effective diets to prevent or reduce obesity in humans, including ketogenic diets, often require radical and daily changes. Eating habits, The author of the study says. These requirements result in very low long-term compliance.

Longo said the study was “Sweet spot “In the case of foot-and-mouth disease in mice on the 5th of the month.

“Since then mouseIn the experimental group, we returned to high fat and high calories diet “The improvement in lipolysis in the body has been going on for quite some time,” said Longo. “Is there a similar sweet spot for humans that can continue to break down fat for weeks after a few days of intervention?”

Early FMD trials show potential health benefits for humans, he added. Some clinical studies published by Longo and colleagues have a monthly FMD Caused a decrease in fat massWithout losing muscle mass Improved risk factors for cardiac metabolismEspecially for people who are overweight or obese. They say that this new mouse study shows that these monthly FMD cycles can actually restore normal heart and metabolic health and longevity in high-fat animals. High calorie diet, Lifelong research that humans cannot do.


A diet that mimics fasting is promising for the treatment of people with inflammatory bowel disease.


For more information:
Amrendra Mishra et al, A diet that mimics fasting prevents the effects of a high-fat diet on the risk of heart metabolism and longevity, Natural metabolism (2021). DOI: 10.1038 / s42255-021-00469-6

Quote: By interrupting a high-fat, high-calorie diet in a regular “fasting” cycle, mice can lead a longer and healthier life: Study (October 14, 2021), https: Obtained October 14, 2021 from //medicalxpress.com/news/2021-10-high-fat-high-calorie-diet-regular-fasting.html

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By interrupting a high-fat, high-calorie diet in a regular “fasting” cycle, mice can lead a longer and healthier life: Studies

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