In a study of dogs with moderate osteoarthritis symptoms, fiber-based implants containing stem cell-derived cartilage reduced pain and returned hip function to baseline levels. Led by researchers at North Carolina State University, Washington University in St. Louis, and Cytex Therapeutics Inc., the study could be an important first step towards prophylactic and non-invasive joint surface reconstruction in dogs and humans. there is.
For humans, and for dogs, a 1 mm thick layer cartilage It can mean the difference between an active lifestyle and painful osteoarthritis. Its small cartilage cap protects the surface of the joint and allows the bones to slide smoothly against each other. Age and joint damage can deteriorate cartilage, causing osteoarthritis and progressive joint pain.
“One of the orthopedic chalices is to replace cartilage, but there was no effective way to do it,” said North Carolina State University, a professor of surgery and translational pain research and research. “Although the focus is on replacing or repairing the surface of cartilage with artificial materials, it is currently not possible to regenerate cartilage, and many of the artificial products used are not integrated into the body. “
Farshid Guilak, a professor of orthopedics at the University of Washington and Shriners Hospitals for Children, founded Cytex Therapeutics with Bradley Estes and Frank Moutos. Implant It can replace damaged or lost cartilage. Implants are created using a unique combination of manufacturing techniques, partly textile and partly 3D printed, allowing the patient’s own stem cells to be seeded.
“By combining 3D printing with advanced textiles, we were able to design implants that mimic the natural functioning of healthy tissues in joints from day one after transplantation,” says Estes. “It was also designed to dissolve over time, eventually returning joint function to the patient’s own tissue during the healing process.”
Researchers have designed a study to test implants to resurface dog joints. This is an important step in using this technique for both dog and human patients.
In this study, cartilage was grown on the implant for several weeks before surgery. The implant was then placed in the damaged area of the hip ball joint. Over time, the implants lysed, eventually leaving only the patient’s own natural tissue in the repaired hip joint.
The dogs in this study were divided into two groups. One is the group that received the implant and the other is the control group that did not. North Carolina State University researcher Russells and his colleagues at North Carolina State University performed surgery and measured subsequent joint pain and function in both groups.
Four months after surgery, the group that received the cartilage implant returned to baseline levels in both function and pain, but the control group never improved. Researchers also saw evidence that the implant was well integrated into the hip and effectively resurfaced the hip.
“What we saw was that these dogs performed as well as or better than the total when using implants. Arthroplasty“Russells says.
“We were thrilled that the implants were very effective in restoring the level of activity in the animals,” says Estes. “After all, this is why patients see a doctor. They want to play tennis, play with their children, and generally re-engage in a painless, active lifestyle that was robbed by. I am thinking. arthritis.. “
Lascelles hopes that implants will address some of the problems associated with complete joint replacement in young and active patients.
“There are significant drawbacks to replacing the entire joint in young patients,” says Lascelles. “Surgery is more complex and artificial joints are only effective for a certain number of years before they have to be replaced, often with bad results every time.
“This procedure is less invasive and the implant uses the body’s own cells and is integrated into the injured area where there is little risk of rejection. This is a major advance in postponing joint replacement in dogs. I think it’s a possible early intervention, preferably one. Human Day. ”
Bradley T. Estes et al, Biological Resurfacing in a Canine Model of Hip Osteoarthritis, Science Advances (2021). DOI: 10.1126 / sciadv.abi5918
North Carolina State University
Quote: Cartilage resurfacing implants reduce pain and restore hip function in dogs (September 15, 2021).
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Cartilage resurfacing implants reduce pain in dogs and restore hip function
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