Changes in the length of the premenopausal menstrual cycle may predict the risk of heart disease

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As women approach menopause, the length of the menstrual cycle often increases. The timing of these changes may provide clues about the risk of people developing heart disease, according to a new study led by researchers at the University of Pittsburgh.

Released today menopause, Research features cycle Length changes Menopausal transition They found that women who had a longer cycle two years before their last menstrual period could more accurately measure vascular health than women who had a stable cycle during this transition.Changes in cycle length, in combination with other menopausal features and health measures, may help clinicians predict which patients may be at higher or lower risk. Cardiovascular disease We recommend preventive strategies.

“Cardiovascular disease is the number one murderer of women, and the risk is significantly increased after middle age, so menopause may contribute to the disease,” said Dr. Samar El Khoudary, an associate professor of epidemiology and lead author. I think there is. ” At the Pitt School of Public Health. “Menopause is more than just a button click. It’s a multi-step transition in which women experience many changes that can increase their risk of cardiovascular disease. Changes in the length of the cycle associated with hormone levels are It’s a simple, easy-to-understand indicator. We are at greater risk. “

The average period of the menstrual cycle is about 28 days, which varies greatly from woman to woman. People with frequent short cycles spend more time at higher estrogen levels than those with fewer long cycles. This variation in hormonal levels may explain why the long and irregular cycle of reproductive years is associated with cardiovascular disease, breast cancer, osteoporosis and other conditions.

El Khoudary and her team wondered if changes in cycle length during the menopausal transition could also predict future cardiovascular health.To answer this question, researchers analyzed data from 428 ongoing participants. Research on women’s health nationwide.. The study followed women aged 45-52 years at enrollment for up to 10 years or until postmenopause. Researchers assessed postmenopausal cardiovascular risk by collecting menstrual cycle data during the menopausal transition and measuring arteriosclerosis or arterial thickness.

Researchers have noted three different trajectories in the length of the menstrual cycle during the menopausal transition. Approximately 62% of participants had a stable cycle that did not change perceptibly before menopause, while approximately 16% and 22% had cycle lengths 5 or 2 years before the last menstrual period, respectively. Experienced an early or late increase defined as an increase in. ..

Compared to women with a stable cycle, women in the slow-increasing group had significantly higher arterial stiffness and thickness measurements, indicating a lower risk of cardiovascular disease. Women in the early increase group had the lowest arterial health measurements.

“These findings are important because they show that women cannot be treated as a group. Women show different menstrual cycle trajectories during the menopausal transition, which trajectories of vascular health. It’s like a marker, “says El Khoudary. “This information is being added to a toolkit being developed by clinicians caring for middle-aged women to assess the risk of cardiovascular disease, approaching the personalization of preventive strategies.”

Researchers have a trajectory of the menstrual cycle menopause Reflection Hormone level, This in turn contributes to cardiovascular health.. In future studies, they plan to assess hormonal changes to test this hypothesis.

According to El Khoudary, why cardiovascular disease The risk was higher for participants in a stable cycle compared to the slow-increasing group. Studies show that high estrogen can protect the heart of young women with short cycles, but this hormone can be less protected in older age.

El Khoudary also wants to investigate whether patterns in the menstrual cycle are associated with other cardiovascular risk factors such as: Abdominal fat, She turned out to have been previously associated Heart disease Menopausal risk woman..

Menopause before age 40, at high risk of stroke

For more information:
Samar R. El Khoudary et al, The pattern of menstrual cycle length during the menopausal transition is associated with postmenopausal asymptomatic atherosclerosis. menopause (2021). DOI: 10.1097 / GME.0000000000001876

Quote: Changes in the length of the premenopausal cycle may predict the risk of heart disease (October 13, 2021).

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Changes in the length of the premenopausal menstrual cycle may predict the risk of heart disease

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