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Common intestinal factors associated with depression and bipolar disorder

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A new study found that the gut bacteria in people with psychiatric disorders such as depression, bipolar disorder, and anxiety have a common overlapping environment.

Study published today JAMA PsychiatryFound that people experiencing these diseases are more likely to have an intestinal biome characterized by both a lack of anti-inflammatory bacteria and an increased amount of inflammatory bacteria. Although these biomarkers are not considered in this study, it suggests that treatment of mental illness should be considered to raise awareness of gut health.

The gut microbiota is a large and dynamic community of microorganisms that inhabit the human gastrointestinal tract. This includes bacteria, viruses, fungi, and other types of microorganisms. In previous studies Gut microbiota It is involved in the development of mental illness.

With a diverse global sample, researchers conducted a meta-analysis of 59 case-control studies, Gut microbiota..

In the study, depression, anxiety, Bipolar disorder Psychosis has consistently been found to have low levels of two anti-inflammatory bacteria in the intestine, Fecaribacterium and Coprococcus. Further analysis revealed that people with these diseases had high levels of Eggerthella, a bacterium with an pro-inflammatory effect.

Viktoriya Nikolova, the first author of King’s IoPPN, said, “We were unable to establish biomarkers for a particular illness, but during intestinal health and the prevalence of psychiatric disorders, especially with anti-inflammatory bacteria. The prevalence of certain inflammatory bacteria compared. “

“As far as we know, this is the first to assess changes in the gut microbiota associated with various psychiatric disorders and to assess their potential as biomarkers,” said Professor Allan Young, Principal Investigator at King’s IoPPN. The composition of the microbial flora is extensive and, although likely to be much more complex, with other known underlying mechanisms of psychiatric disorders, such as regulation of inflammatory processes. There are signs that they are related to each other. It is becoming increasingly clear that the health of the gut microbiota is crucial to the wider mental health of the individual. ”


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For more information:
Viktoriya L. Nikolova et al, Perturbation of gut microbiota composition in psychiatric disorders, JAMA Psychiatry (2021). DOI: 10.1001 / jamapsychiatry.2021.2573

Quote: Common factors in the intestine associated with depression and bipolar disorder (September 15, 2021) are https: //medicalxpress.com/news/2021-09-common-factors-gut-depression-bipolar Obtained from .html on September 15, 2021

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Common intestinal factors associated with depression and bipolar disorder

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