Common steroids after “long COVID” recovery can reduce the risk of death by up to 51%

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Evidence continues to be gathered that “long COVID”, that is, continued adverse health effects months after a clear recovery from severe COVID-19, is a significant risk for some patients. .. For example, researchers at the University of Florida Gainesville found that inpatients who appeared to have recovered from severe COVID-19 experienced only mild or moderate symptoms and were not hospitalized or had illness. People without.

Currently, a team of several from the same author is the first to show severe systemic appearance of recovery among patients admitted with COVID-19. inflammation It is a risk factor for death within a year during hospitalization. This may seem paradoxical, as inflammation is a natural part of the body’s immune response that has evolved to fight infection. However, in some illnesses, including COVID-19, this reaction can be overkill and even more harmful.

“COVID-19 is known to cause inflammation, especially during the first acute episode. Our study found that COVID-19 was inflamed during hospitalization and mortality after the patient” recovered “. This is the first study to investigate the relationship between the two, “said the lead author’s professor. .Arch G. Mainous III, Vice-Chair of Research, School of Community Health and Family Medicine, University of Florida, Gainesville.

“Here we show that the stronger the inflammation during the initial hospitalization, the more likely the patient will die within 12 months of appearing to have” recovered “from COVID-19. “

Mainous et al. Investigated anonymized electronic health records of 1,207 adults admitted in 2020 or 2021 who were positive for COVID-19 in the University of Florida’s health system and were followed for at least one year after discharge. Did. As a substitute for the severity of systemic inflammation during hospitalization, they are common and validated measurements, blood levels of molecular C-reactive protein (CRP) secreted by the liver in response to signals from active immune cells. Was used.

Inflammation of many parts of the body

As expected, blood levels of CRP during hospitalization were strongly correlated with the severity of COVID-19. It was 59.4 mg / L for inpatients who did not require oxygen supplementation and 126.9 mg / L for non-invasive and extra oxygen-requiring patients. 201.2 mg / L for the most severe cases requiring ventilation, non-mechanical ventilation, and ventilation by mechanical ventilation or extracorporeal membrane oxygenation.

Patients with COVID-19 with the highest CRP levels measured during hospitalization were 61% more at risk of dying for any reason within the first year of discharge than patients with the lowest CRP levels (other risks). Correct the factor).These results are published in Medical frontier..

“Many infections are associated with increased inflammation. In most cases, inflammation is concentrated or identified at the site of infection. COVID-19 is found in many places other than the respiratory tract, such as the heart. It is different because it causes inflammation in the brain, kidneys, etc. Severe inflammation can lead to tissue damage. “

Importantly, the authors showed that when patients were prescribed anti-inflammatory steroids after admission, the increased risk of death from any cause associated with severe inflammation was again reduced by 51%.

These results mean that the severity of inflammation during hospitalization for COVID-19 can predict the risk of subsequent serious health problems, including death from long COVID. They also suggest that current recommendations for best practices may need to be modified to include a broader prescription of steroids taken orally in COVID-19 patients at discharge.

COVID-19: Chronic disease?

The authors suggest that COVID-19 should be considered a potentially chronic disease.

“When someone has a cold or pneumonia, we usually think that the illness is over when the patient recovers, such as congestive heart failure or diabetes, which continues to affect the patient after an acute episode. Unlike chronic illnesses. Similarly, COVID-19 should begin to be considered to have continuous effects on many parts of the body after the patient recovers from the first episode, “Mainous said. increase.

Once you realize the importance of “long COVID” after it looks like “recovery”, you need to focus on treatments to prevent problems after stroke, brain dysfunction, especially premature death. ”

Severe COVID-19, neuropsychiatric sequelae similar to SARI

For more information:
Effect of Early COVID-19 Episode Inflammation in Adults on Mortality Within 12 Months After Discharge: Cohort Study, Medical frontier (2022). DOI: 10.3389 / fmed.2021.778434 ,… med.2021.778434/full

Quote: Common steroids after “long COVID” recovery have a maximum mortality risk taken on May 12, 2022 from https: // % (May 12, 2022) May Reduce Recovery-death.html

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Common steroids after “long COVID” recovery can reduce the risk of death by up to 51%

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