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Early Findings of Alzheimer’s Disease Research in Diverse Populations Available to Researchers

Dr. O’Brient announced the availability of research data in an article published in the national journal Alzheimer’s Disease and Dementia: Diagnosis, Assessment, and Disease Monitoring, published by the Alzheimer’s Disease Association on June 21. .. Credit: HSC

A growing pile of data to help scientists understand the biology of Alzheimer’s disease among diverse populations in the context of sociocultural, behavioral, and environmental factors is the Health of North Texas University in Fort Worth. Available through the Translational Research Institute at the Science Center (HSC)).

TheĀ· Research data This is the result of a Latin American Elderly Health and Aging Brain (HABLE) study initiated in 2017, funded by the National Institutes of Health, $ 12 million, and the Institute’s Executive Director. It is led by Dr. Sid O’Brient.

In 2020, the HABLE study received an additional $ 45 million from the National Institute on Aging, which is part of the National Institutes of Health.

Dr. O’Brient announced the availability of research data in an article published on June 21st. Alzheimer’s disease and dementia: diagnosis, evaluation, disease monitoring, A national magazine published by the Alzheimer’s Association.

“The data from this study is the first in the field,” said Dr. O’Brient. “For the first time, we will be able to examine the biology of Alzheimer’s disease between Mexican-Americans and non-Hispanic whites, all in the context of sociocultural, environmental and behavioral factors. Scientists around the world can use this data to address health disparities and define new diagnostic and therapeutic opportunities for underserved communities. “

According to the paper, the proportion of Hispanics aged 65 and over in the United States has tripled by 2050 and will experience the largest increase in Alzheimer’s disease-related dementia by 2060 when compared to other racial or ethnic groups. It is expected that. About 65 percent of Hispanics in the United States are decent in Mexico.

However, Mexican-Americans are severely underestimated in studies of Alzheimer’s disease, and there are few comprehensive studies on biomarkers of the disease in this population. Early findings indicate that beta-amyloid protein, one of the biomarkers of Alzheimer’s disease, is less common among Mexican-Americans, but Mexican-Americans appear to have a younger onset of cognitive loss. Suggests.

Approximately 1,000 Mexican-Americans and more than 50 non-Latin Caucasians from Northern Texas enrolled in the study, with regular and free comprehensive interviews, functional tests, laboratory tests, and brains for participants. We offer MRI and state-of-the-art PET scans.

PET scans allow researchers to observe the differences over time in the development of biomarkers between Mexican-Americans and non-Latin Caucasians.

In December, HSC announced an additional $ 7 million investment to add 1,000 African Americans to the study. Among people over the age of 65, African Americans have the highest prevalence of Alzheimer’s disease diseaseAccording to the US Centers for Disease Control and Prevention, followed by Hispanic and non-Latin whites.

This project is the only comprehensive and large-scale research study on the three largest Alzheimer’s diseases. Ethnic group In the United States-Non-Hispanic Caucasians, Mexican-Americans, African-Americans.


Sleep deprivation predicts longer-term Hispanic cognitive decline than Caucasians


For more information:
Sid E. O’Bryant et al, Latin Elderly Health and Aging Brain (HABLE) Research Methods and Participant Characteristics, Alzheimer’s disease and dementia: diagnosis, evaluation, disease monitoring (2021). DOI: 10.1002 / dad2.12202

Courtesy of the University of North Texas Health Sciences Center

Quote: Early discoveries of Alzheimer’s disease research in diverse populations available to researchers (25 June 2021), https: //medicalxpress.com/news/2021-06-early-alzheimer- Obtained June 25, 2021 from diverse-populations.html

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Early Findings of Alzheimer’s Disease Research in Diverse Populations Available to Researchers

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