Eating less fat may save your hair

Appearance of mice fed a high-fat diet (right) and a standard diet (left).Credit: Department of Stem Cell Biology, Tokyo Medical and Dental University

It is well known that obesity is associated with the development of many human illnesses. Heart disease, diabetes, and other illnesses are very common in obese people. However, it is not entirely clear how the body’s organs specifically deteriorate and lose their function due to chronic obesity.In a recent article published in Nature, Tokyo Medical and Dental University (TMDU), a group of researchers used mouse model experiments to investigate how a high-fat diet or genetically induced obesity affects thinning hair and hair loss. The authors show that obesity can cause depletion of hair follicle stem cells (HFSCs) through the induction of certain inflammatory signals, inhibit hair follicle regeneration, and ultimately result in hair follicle loss. discovered.

Normally, HFSC self-renews every hair follicle cycle. This is part of the process that allows our hair to grow continuously. As humans grow older, HFSCs are unable to replenish themselves, resulting in less HFSCs and therefore thinning hair. Overweight people are at increased risk of androgenic alopecia, but little is known about whether obesity accelerates thinning hair, how, and the molecular mechanism. The TMDU Group has identified several mechanisms aimed at addressing these issues.

“A high-fat diet promotes thinning hair by depleting HFSC, which replenishes mature cells that grow, especially in older mice,” said Hironobu Morinaga, lead author of the study. “The gene expression of HFSC was compared between mice fed HFSC and mice fed a standard diet and the fate of those HFSCs after activation was followed.” HFD-fed obese mice. HFSC has been found to alter the fate of keratinocytes on the surface of the skin. Or keratinocytes that secrete sebum when they are activated. These mice show faster hair loss and smaller hair follicles with HFSC depletion.

Eating less fat may save your hair

Fate-following analysis of hair follicle stem cells (HFSC) revealed that HFSC diverts to desquamation epidermal keratinocytes or sebum-secreting cells. Triglyceride stains are shown in red.Credit: Department of Stem Cell Biology, Tokyo Medical and Dental University

“HFSC shows increased oxidative stress and signs of epidermal differentiation, even after 4 consecutive days of HFD.”

“NS Gene expression HFSC in high-fat diet mice showed activation of inflammatory cytokine signaling within HFSC, “said senior author Emi K. Nishimura. “The inflammatory signal of HFSC significantly suppresses sonic hedgehog signaling, which plays an important role in HFSC hair follicle regeneration.

Researchers have confirmed that activation of the Sonic hedgehog signaling pathway in this process can save HFSC depletion. “This can prevent the hair loss caused by High-fat diet.. “Nishimura said.

This study is interesting for certain cell fate changes and tissue dysfunction that can occur after a high-fat diet or genetically induced obesity and may open the door to future prevention and treatment. Provides new insights hair For thinning and understanding obesityRelated illness.

Bald Truth — Changes in Cell Division Cause Thinning Hair

For more information:
Morinaga Hironobu et al., Obesity promotes thinning hair by a stem cell-centered convergence mechanism. Nature (2021). DOI: 10.1038 / s41586-021-03624-x

Provided by Tokyo Medical and Dental University

Quote: Reducing fat may save hair (September 21, 2021) September 21, 2021 Obtained from

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