Effective drugs for nanodiamonds in the fight against oral infections

ND acts as an effective drug against both floating and attached cells (biofilms) of bacteria and fungi that are highly associated with oral and systemic infections. Credit: DOI: 10.1039 / D1BM00608H

Diamonds are gems and gems used in the industry. However, in the not too distant future, diamond nanoparticles or nanodiamonds (ND) may contribute to oral health.

Oral diseases like decay (Attenuation), Periodontal disease When Fungal infection Is a major medical problem worldwide, with millions of dollars spent each year.Complex microbial communities, usually occur as follows disease-Bacteria and fungi attach to the tooth surface to form biofilm communities, which are the main causes of infection. The National Institutes of Health states that 65 to 80 percent of all human infectious diseases are caused by biofilms.

In a journal article published in Biomaterial science For the first time, scientists from the University of Hong Kong’s Faculty of Engineering and School of Dentistry (HKU), entitled “Nanodiamonds Inhibit Oral Pathogen Biofilms,” have demonstrated the inhibitory effects of high pressure and high pressure on oral pathogen biofilms. -Temperature (HPHT) nanodiamonds.

The co-principal investigators of the study are Dr. Chu Zhiqin, an assistant professor in the Department of Electrical and Electronic Engineering, and Dr. Prasanna Neelakantan, an assistant professor in endocrinology, who report that ND functions as an effective drug for both floating cells. (Bacterial and fungal floating cells that are highly associated with oral and systemic infections) and adherent cells (biofilms). In particular, they have demonstrated the role of NDs in inhibiting biofilm formation and their disruptive effects on preformed biofilms in some selected oral and systemically important organisms.

Caries affects more than 3 billion people (48% of the population) worldwide. They are caused by the predominance of acid-producing bacteria that form biofilms on the tooth surface. The gram-positive bacterium Streptococcus mutans (S. mutans) is considered to be crucial for the development of the disease. Periodontal disease is the sixth most common disease in humans, with a global prevalence of 11.2% and is caused by the gram-negative bacterium Porphyromonas gingivalis (P. gingivalis).In particular, microbial dysbiosis Oral cavity It is associated with systemic diseases such as obesity, Alzheimer’s disease and cardiovascular disease. These microorganisms are highly resistant to traditional antibiotics, and alternatives, including nanotechnology, are being sought intensively to provide more efficient treatments.

In addition, another major oral disease of clinical significance, fungal infections, has seen no progress in therapeutic drug development over the past few decades.

“Nanomaterials are a hot topic in materials science today because these microparticles can effectively penetrate microorganisms and also carry a wide variety of drugs. Our research is on these ultra-small particles. Small nanodiamonds prevent and therefore inhibit pathogens and their adhesion to their surface Biofilm Formation in the oral cavity, “explained Dr. Chu and Dr. Neelakantan.

“The results of this exciting study show the great potential of ND as an alternative therapeutic platform for the prevention and treatment of oral infections. ND has many features, including excellent biocompatibility and flexible surface properties. It has promising features and has proven to be very safe for humans. Studies have promoted a better mechanistic understanding of ND on oral pathogens and their clinical and translational applications. Will pave the way for, “they added.

This knowledge and impact of ND is an antifungal drug, especially for those who are vulnerable to fungal infections, including very old and very young, and those who are immunocompromised due to such diseases. As can be translated to prevent other life-threatening infections in the body, such as HIV infections and diabetes, chronic users of steroids, cancer patients receiving chemotherapy, etc. Since fungal cells are very similar to human cells, the development of antifungal agents that do not harm humans has always been a major challenge.

Researchers unravel the physicochemical mechanism of plaque-forming micromolecules

For more information:
Tongtong Zhang et al, Biofilm Inhibition of Oral Pathogens by Nanodiamonds, Biomaterial science (2021). DOI: 10.1039 / D1BM00608H

Quote: Nanodiamond Effective Agents in Addressing Oral Infections (September 22, 2021), https: // 2021 Obtained on September 22nd.

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Effective drugs for nanodiamonds in the fight against oral infections

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