Evaluation of lupus arthritis using frequency domain optical imaging

An example of a frequency domain image of a knuckle (proximal interphalangeal joint of the index finger) affected by lupus arthritis.Credit: NYU Tandong Institute of Technology

Systemic lupus erythematosus (SLE), commonly referred to simply as “lupus,” is an autoimmune disease in which the body’s immune system attacks healthy tissues. Lupus affects somewhere between 20 and 150 per 100,000 people, depending on race and ethnicity. The disease often causes symptoms of arthritis in the joints and can be debilitating in some cases.

Identification of lupus, despite the severity of the disease arthritis And the evaluation of that activity remains an issue in clinical practice. Evaluations based on traditional collaborative testing lack accuracy due to the subjective nature and accuracy of situations such as obese fingers and coexisting fibromyalgia. As a result, these tests have limited ability to provide quantitative data on improvement and deterioration.

Recently, with imaging technology, especially ultrasound (USA) Magnetic resonance Imaging (MRI) has enabled a more objective and detailed assessment of joint and periarticular abnormalities with greater sensitivity. However, MRI and the United States are expensive and time consuming. In addition, the United States has been found to be heavily dependent on operators. Therefore, both modality is not really used on a daily basis today. There is a clear unmet need for a simple, reliable, non-invasive, low-cost diagnostic imaging method that can objectively assess and monitor the progression of arthritis in lupus patients.

Currently, NYU Tandon researchers are working with Columbia University to explore optical imaging technology as a reliable method for diagnosing patients and assessing disease progression. Researchers, including Assistant Professor Alessandro Marone and Dean of the Department of Biomedical Engineering, Andreas H. Heelscher, can use frequency-domain optical imaging to reliably identify lupus arthritis and track how the disease has progressed. I found.

The results provide strong evidence of the frequency domain Optical image It can provide objective and accurate insights into SLE that was not possible or economically feasible with other technologies. Diffusion of light confirmed inflammation of blood vessels around the joints, similar to but different from the symptoms caused by rheumatoid arthritis. With this technology, caregivers may not have to rely on patient feedback to track the progression of lupus, but they can see lupus in action.

Optical imaging has been used in studies comparing osteoarthritis, rheumatoid arthritis (RA), and healthy controls. The results of those studies emphasized that patients suffering from RA have higher light absorption in the joint space compared to healthy subjects. This may be due to the presence of inflammatory synovial fluid, which reduces the transmission of light through the inflamed joint. However, these observations have never been used in lupus studies, and these findings may provide a reliable, rapid and cost-effective method for assessing joint lesions in lupus patients. There is sex.

What do you know about rheumatoid arthritis?

For more information:
Alessandro Marone et al, Evaluation of SLE Arthritis Using Frequency Domain Optical Imaging, Lupus science and medicine (2021). DOI: 10.1136 / lupus-2021-000495

Quote: Evaluation of lupus arthritis using frequency domain optical imaging (September 30, 2021) from https: // 2021 Obtained on September 30th.

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Evaluation of lupus arthritis using frequency domain optical imaging

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