Gd-doped nanoclusters help in imaging early orthotopic cancers

3 O Four Schematic of the mechanism of T2 relaxation rate enhanced by Gd doping of nanoclusters. Credit: Gan Yuehao “width =” 800 “height =” 529 “/>

Schematic diagram of the mechanism of Gd doping-enhanced T2 relaxation rate of iron3OFour Nano cluster. Credit: Gan Yuehao

High-resolution magnetic resonance imaging (MRI) with the help of contrast media is essential to achieve an accurate diagnosis of early-stage cancer for effective treatment and a better prognosis. Iron oxide based T2 MR contrast agents (IOCA) face the serious problem of strong ferromagnetism and the resulting weak T.2 Contrast ability. Gadolinium ion (Gd3 years and over) Doping, the specific role of Gd3 years and over What was played in this process remained unknown.

Researchers led by the Chinese Academy of Sciences (CAS) Hefei Institute of Materials Science (HFIPS), Institute of Health Sciences, and Professor Wu Zhengyan of Binzhou Medical University have produced a series of Gd-doped iron oxide nanoclusters. Systematically study the unique mechanism by which Gd doping regulates T2 Contrast capability of nanoclusters.

Researchers have found that as the doping content increases, GdxFe increases.3-xOFour The nanoclusters characterized by ferromagnetism have changed to superparamagnetism, and the specific surface area of ​​the nanoclusters has increased significantly, leading to a collectively strong T.2 Contrast.

“I got the best r2 Value, 4 times the original Fe3OFour“Gan Yuehao, the first author of the study, said,” Gd contrast0.018Fe2.982OFour Nano cluster It provides a possible method for diagnosing early orthotopic cancer in mice. “

This work paves the way for the development of an atomically accurate Gd-doped MMION as an efficient T.2-Weighted MRI Contrast Agent.

This study is published in Chemical Engineering Journal

Near-infrared synergistic therapy for cancer nanoclusters

For more information:
Yuehao Gan et al, Atomically Accurate Multidomain GdxFe3-xO4 Nanocluster with Modulated Contrast Characteristics for T2-Enhanced Magnetic Resonance Imaging of Early Orthotopic Cancers, Chemical Engineering Journal (2021). DOI: 10.1016 / j.cej.2021.132255

Quote: Gd-doped nanoclusters are early orthotopic cancers obtained from on September 15, 2021. Useful for imaging (September 15, 2021)

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Gd-doped nanoclusters help in imaging early orthotopic cancers

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