Heterogeneous development of children with congenital Zika syndrome-related microcephaly

Hammersmith Infant Neurological Examination score for children with congenital Zika syndrome associated with microcephaly. A) Main Section-Neurological Examination; B) Second Section-Motor Milestone. C) Third section-Child behavior. Credits: Aguilar Ticona et al, 2021, PLOS ONE (CC-BY 4.0, / licenses / by / 4.0 /)

Children born with neurological abnormalities due to congenital Zika virus (ZIKV) used routine neurological assessments at the age of two, according to a new study published this week in the Open Access Journal. It has various neurodevelopmental profiles that can be tracked. PLOS ONE By Dr. Albert Ko of Yale University in the United States and Dr. Federico Costa of the Federal University of Bahia in Brazil and their colleagues.

Children infected with the Zika virus in the womb can develop clearly Neurological disorders, Microcephaly, central nervous system malformations, etc. A previous study showed a delay in neurodevelopment of about 20 months in infants with congenital Zika syndrome (CZS) -related microcephaly. However, there have been reports of cases explaining infants with normal neurodevelopmental development, despite showing symptoms similar to CZS-related microcephaly at birth.

In a new study, researchers tracked 42 CZS-affected children between 25 and 32 months from a microcephaly outpatient clinic in Brazil. A total of 19 (45.2%) of the enrolled children were male, with a median age of 28 months at evaluation, and all children had a head circumference that was more than 2 standard deviations below average. .. Participants were evaluated for neurology and neurodevelopment using the Hammersmith Infant Neurological Examination (HINE) and the Bayley Scales of Infant and Toddler Neurodevelopment (Bayley-III), respectively.

In general, children exhibited severe language, cognitive and motor retardation, as measured by Bayley-III, and severe neurological symptoms as recorded by HINE. However, the raw scores of HINE and Bayley-III effectively captured the heterogeneity of these symptoms. Larger head circumference at follow-up was associated with higher cognition (β = 1.27; 95% CI = 0.01–2.53) and motor activity score (β = 2.03; 95% CI = 0.25–3.81). Better HINE scores also correlated with higher Bayley-III cognitive and athletic student scores, even after controlling other factors. This study was the first to link HINE, a short and simple neurological examination tool, to cognitive and motor development in children with CZS. The authors conclude that HINE may be a useful tool to characterize long-term outcomes in children with CZS-related microcephaly and to capture clinical heterogeneity.

The author adds: Microcephaly Indicates severe neurodevelopmental disorder.However, they have different development patterns and you need to understand these differences. Children To provide better health interventions. ”

One-third of children up to 3 years old exposed to Zika in utero have neurological problems

For more information:
Aguilar Ticona JP, Nery N Jr, Doss-Gollin S, Gambrah C, Lessa M, Rastely-Júnior V, et al. (2021) Heterogeneous development in children with congenital Zika syndrome-related microcephaly. PLoS ONE 16 (9): e0256444.

Quote: Heterogeneous-children-congenital-zika-syndrome- https: // Obtained from associated.html on September 15, 2021

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Heterogeneous development of children with congenital Zika syndrome-related microcephaly

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