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High expectations for “universal” mRNA

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The coronavirus pandemic has spawned vaccines from Pfizer / BioNTech and Moderna, and the mRNA technology they use for their common names.

Although these types of jabs are new, researchers have been looking for ways to use messenger RNA for other vaccinations and treat diseases from AIDS to cancer for decades.

How does it work?

The work of messenger RNA in the body comes from DNA cell..

For Pfizer / BioNTech and Moderna jabs, lab-generated mRNA is Human cells It creates an antigen that is a protein similar to that found in the COVID-19 virus.

Thanks to those antigens, Immune system Learn how to fight the virus and neutralize COVID if it gets into your body.

After the cells make these proteins, the body breaks down the mRNA instructions and removes them.

Such direct communication with cells is innovative. A classic vaccine aimed at eliciting an immune response by injecting a neutralized form of a virus or antigen into the system.

Where did this come from?

The first major advance in the late 1970s was the use of mRNA to force in vitro cells to produce proteins.

Ten years later, scientists were able to achieve the same results in mice, but mRNA had two major drawbacks as a medical tool.

For one thing Living animals Resisted synthetic mRNA and caused danger Immune response..

Moreover, mRNA molecules are fragile and difficult to deliver to the system without modifying them.

In 2005, researchers at Penn State University, Katalin Kariko and Drew Weissman, published a groundbreaking study showing that lipid (or fat molecule) envelopes can safely deliver mRNA without adverse effects.

The study has become a hot topic in the pharmaceutical industry, and start-ups specializing in mRNA therapy have begun to emerge around the world.

What else can mRNA do?

Scientists have been working on the development of mRNA jabs for diseases such as seasonal flu, rabies, and Zika fever, as well as diseases that have traditionally maintained vaccine resistance, such as malaria and AIDS.

Researchers have also begun testing personalized treatments Cancer patients, Create a specialized mRNA using a sample of protein in the tumor.

This triggers the immune system to target specific cancer cells.

“The mRNA platform is versatile,” Norbert Pardi, a biochemist at the University of Pennsylvania, told AFP. “Any protein can be encoded as mRNA, so it has many potential uses.”


Sanofi in France discontinues development of mRNA covid vaccine


© 2021 AFP

Quote: From COVID to Cancer: https: //medicalxpress.com/news/2021-10-covid-cancer-high-versatile-mrna.html “multipurpose” mRNA obtained on October 15, 2021 (2021, High expectations for (October 15)

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High expectations for “universal” mRNA

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