A team led by engineers at Johns Hopkins University understood how and why human cells move much faster through thick mucus than thin mucus. People with certain illnesses, such as asthma and COVID-19, secrete 2,000 times more mucus than normal. Cells have fin-like “frills” that help them sense viscosity and know when to change shape to force through the thickest mucus.Survey results released today Nature Physics..
The findings may inform and inspire new treatments for mucin-related disorders, including chronic lung and mucinous cancers (the most deadly subtypes of lung and ovarian cancers).
Engineers have found that not only do certain cells passively experience the surrounding fluid, but they also use “frills” (up and down wavy cell membranes) to examine the fluid and adapt it to its viscosity. Previously, frills were considered a useless accessory.But frills like fins promote cell finished Thick mucusHelps swim faster with something thicker than more watery liquids. The research team included members from the University of Toronto and Vanderbilt University.
Jian Liu, Membrane Rippling is a mechanosensor for extracellular fluid viscosity, Nature Physics (2022). DOI: 10.1038 / s41567-022-01676-y.. www.nature.com/articles/s41567-022-01676-y
Johns Hopkins University
Quote: How cells pass through the most sticky mucus (July 25, 2022) is from https: //phys.org/news/2022-07-cells-stickiest-mucus.html 2022 Obtained on July 25th.
This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. The content is provided for informational purposes only.
How cells pass through the most sticky mucus
Source link How cells pass through the most sticky mucus