How cells pass through the most sticky mucus

Credit: Johns Hopkins University

A team led by engineers at Johns Hopkins University understood how and why human cells move much faster through thick mucus than thin mucus. People with certain illnesses, such as asthma and COVID-19, secrete 2,000 times more mucus than normal. Cells have fin-like “frills” that help them sense viscosity and know when to change shape to force through the thickest mucus.Survey results released today Nature Physics..

The findings may inform and inspire new treatments for mucin-related disorders, including chronic lung and mucinous cancers (the most deadly subtypes of lung and ovarian cancers).

Engineers have found that not only do certain cells passively experience the surrounding fluid, but they also use “frills” (up and down wavy cell membranes) to examine the fluid and adapt it to its viscosity. Previously, frills were considered a useless accessory.But frills like fins promote cell finished Thick mucusHelps swim faster with something thicker than more watery liquids. The research team included members from the University of Toronto and Vanderbilt University.

Credit: Johns Hopkins University

New studies have identified a major set of signals that control pulmonary mucus production

For more information:
Jian Liu, Membrane Rippling is a mechanosensor for extracellular fluid viscosity, Nature Physics (2022). DOI: 10.1038 / s41567-022-01676-y..

Quote: How cells pass through the most sticky mucus (July 25, 2022) is from https: // 2022 Obtained on July 25th.

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How cells pass through the most sticky mucus

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