How many more final warnings do you have before it’s too late?

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This year’s WHO-approved special session at the European Conference on Clinical Microbiology and Infectious Diseases (ECCMID) warns the world of the need before it’s too late to address the growing threat of antimicrobial resistance (AMR). Ask how many more. Of medicine.

The panel, including former UK Chief Medical Officer Professor Dame Sally Davies (now the UK’s Special Envoy for AMR), has made minor progress in recent years, despite multiple summons and warnings of all-threatening antibiotic apocalypse. Consider.Include Modern medicine We depend on our daily lives.

“The collapse of the antibiotic market has sounded a warning. The $ 100 million loss of antibacterial drugs compared to the $ 8 billion profit of anticancer drugs is not due to bankruptcy, but a lack of scientific brains. It means that the medicine rack is empty, “explains Dame Sally. “Currently, patients are paying because of the market downturn and lack of access. Future generation You will suffer even more. “

She says this trend is not sustainable, especially if COVID-19 shows how many patients worldwide depend on scientific innovation. “I’ve said,’I don’t have time to wait,’ but it’s too late for many. They’re dead. Unless you take action now, the alarm bell will soon become the death bell of modern medicine. It will change, “says Dame. Sally.

With more innovation, experts believe that AMR can be contained.Last month, the G7 countries New antibiotic.. In the United States, the PASTEUR Act (voting by the US House of Representatives and Congress pending) represents a breakthrough mechanism of “pulling” to reach patients who need new antibiotics most.

The hope that the PASTEUR law provides is clear. Under this law, the US federal government provides market incentives for developing life-saving antibacterial agents. Pharmaceutical companies / developers are paid annually the contractually agreed amount for a five-year agreed period up to the antimicrobial patent term. These contracts will facilitate the development of new antibacterial agents.

Specifically, such contracts are against “super bugs,” which are considered the most threatening by the Centers for Disease Control and Prevention (CDC), which includes bacteria such as Candida auris, fungi, Clostridium difficile and carbapenem-resistant Acinetobacter. Promote the development of antibacterial drugs. Pasteur-based contracts also serve as an incentive to develop a new class of antimicrobials with a whole new mechanism of action to combat these drug-resistant infections.

Meanwhile, the UK has launched the world’s first “Netflix-style” payment model. Pharmaceutical company A fixed amount by subscription for access to innovative antibiotic products, not a price based on product usage. In December 2020, the UK government chose two antibacterial agents, Shionogi’s Fetcroja (Cefiderocol) and Pfizer’s Zavicefta (Cefzidime and Avivactum) (Zavicefta), and purchased them in a Netflix-style subscription payment model. The European Union’s pharmaceutical strategy, announced in 2020, is also working to implement a new “pull” model to further boost the new sick antibacterial pipeline.

Dame Sally concludes: “It is our joint responsibility to ensure that our research and policymaking reflect this. From early-stage research to clinical trials to patient access, inclusiveness drives our innovation. We need to define. Globally, we need to move forward, working together across sectors and countries. ”

New treatment for multidrug-resistant bacteria

Courtesy of the European Society of Clinical Microbiology and Infectious Diseases

Quote: Antibiotic resistance: How many more final warnings do you have before it’s too late? (July 9, 2021) Obtained July 9, 2021 from https: //

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How many more final warnings do you have before it’s too late?

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