Tech

Innovative Silicon Nanochips Can Reprogram Living Tissues

Credits: Indiana University

Silicon devices that can transform skin tissue into blood vessels and nerve cells have evolved from prototypes to standardized manufacturing. In short, it can now be manufactured in a consistent and reproducible way.As reported in Nature protocolDeveloped by researchers at Indiana University School of Medicine, this study brings the device one step closer to its potential use as a treatment for people with a variety of health concerns.


This technique, called tissue nanotransfection, is a non-invasive nanochip device that can reprogram tissue function by applying harmless electric sparks to deliver specific genes in a matter of seconds.In laboratory studies, the device was successfully converted Skin tissue Into Blood vessels Repair a severely injured leg.This technique is currently being used to reprogram tissues for various types of treatments such as repair. Brain injury It is caused by the prevention and reversal of nerve damage from stroke or diabetes.

“This report on how to accurately manufacture these tissue nanotransfection chips will allow other researchers to participate in this new development. Regenerative medicineChandansen, director of the Indiana Center for Regenerative Medicine Engineering, said he is the Vice President and Special Professor of Research at the IU School of Medicine.

Sen also leads the pillars of regenerative medicine and engineering science in the IU Precision Health Initiative and is the lead author of new publications.

“This little silicon Tip It enables nanotechnology that can change the function of some parts of the body, “he said. Blood supplyYou can’t rely on this because the existing blood vessels are crushed, but you can convert the skin tissue into blood vessels and save the endangered limbs. “

In Nature protocol According to the report, researchers have released engineering details on how to make chips.

Sen said the manufacturing information would lead to further development of the chip, hoping that it would one day be used clinically in many environments around the world.

“This is about chip engineering and manufacturing,” he said. “The chip nanofabrication process usually takes 5-6 days and can be accomplished by anyone skilled in the art with the help of this report.”

Sen said he hopes to seek FDA approval for the chip within a year. With FDA approval, the device can be used for clinical research in people, including patients in hospitals, medical centers, and emergency rooms, as well as other emergencies by first responders and the military.


An epoch-making device heals organs with one touch


For more information:
Yi Xuan et al, Manufacture and Use of Silicon Hollow Needle Arrays to Achieve Tissue Nanotransfection of Mouse Tissue in vivo, Nature protocol (2021). DOI: 10.1038 / s41596-021-00631-0

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Indiana University

Quote: Innovative silicon nanochips are biotissues obtained from https://phys.org/news/2021-11-silicon-nanochip-reprogram-biological-tissue.html on November 29, 2021 (November 2021). May 29th) can be reprogrammed.

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Innovative Silicon Nanochips Can Reprogram Living Tissues

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