Inspired by paper-cutting art, stents can deliver medicine to the gastrointestinal tract

This device has two important elements. A soft, stretchy tube made of silicone-based rubber and a plastic coating etched with needles that pop out when the tube is stretched. Credit: MIT

MIT engineers and their collaborators are inspired by Japanese kirigami, which folds and cuts paper to create three-dimensional structures, and can be used to deliver drugs to the gastrointestinal tract, respiratory tract, and other tubular organs. Designed a type of stent. In the body.

The stent is coated with a smooth layer of plastic etched with a small “needle” that pops up when the tube is stretched, allowing the needle to penetrate. Organization Deliver the payload of medicine-Contains fine particles. These drugs are released over a long period of time after the stent is removed.

This kind of localization Drug delivery May be easier to handle Inflammatory disease It affects the gastrointestinal tract, such as inflammatory bowel disease and eosinophilic esophagitis, said Giovanni Traverso, MIT’s assistant professor of mechanical engineering, gastroenterologist at Brigham and Women’s Hospital, and lead author of the study. I will.

“This technique can be applied to essentially any tubular organ,” says Traverso. “In rare cases, having the ability to deliver drugs locally can really maximize the potential to help resolve the patient’s condition and change our mindset. Patient care By allowing topical and long-term drug delivery after a single treatment. “

MIT research scientist Sahab Babaee today Nature Materials..

Elastic stent

Inflammatory bowel diseases of the gastrointestinal tract, such as IBD, are often treated with drugs that weaken the body’s immune response. These drugs are usually injected, so they can have side effects elsewhere in the body. Traverso and his colleagues wanted to come up with a way to deliver such drugs directly to the affected tissue to reduce the potential for side effects.

Stents may provide a way to deliver drugs to the target area of ​​the gastrointestinal tract, but it is difficult to insert any type of stent into the gastrointestinal tract because digested food moves continuously through the gastrointestinal tract. It may be. To make this possibility more feasible, the MIT team came up with the idea of ​​creating a stent that would be temporarily inserted, stay firmly in the tissue to deliver the payload, and be easily removed.

The stents they designed have two important components. A soft, stretchy tube made of silicone-based rubber and a plastic coating etched with needles that pop out when the tube is stretched. This design was inspired by the paper cuts that Traverso’s lab previously used to design non-slip coatings on soles. Others have used it to create a bandage that adheres more firmly to the knees and other joints.

“The novelty of our approach is the ability to deposit drug stores directly into the luminal walls of tubular organs, using tools and concepts from mechanics, in combination with bioinspiration from animals with scaly skin. We have developed a new class of drug release system with sustained release. ” “Kirigami stents now provide a reversible shape transformation from a flat needle for meshing with tissue to a 3D buckled needle and back to the original flat shape for easy and safe removal. It was designed. “

In this study, the MIT team coated plastic needles with fine particles that could carry the drug. After the stent is inserted endoscopically, the endoscope is used to inflate the balloon inside the tube and extend the tube. When the tube is stretched, the pulling action causes the plastic needle to pop out, releasing the cargo.

“It’s a dynamic system where you have a flat surface, and you can make these little needles that pop up and drive into tissue for drug delivery,” says Traverso.

For this study, researchers created several different sizes and shapes of kirigami needles. By varying these characteristics and the thickness of the plastic sheet, researchers can control how deep the needle penetrates the tissue. “The advantages of our system apply to scales of various lengths, Gastrointestinal tract Or any tubular organ, “says Babaee.

GI drug delivery

Researchers tested the stent by inserting it into the esophagus of a pig endoscopically. When the stent was placed, researchers inflated a balloon inside the stent to allow the needle to pop out. The needle, which penetrated the tissue about 0.5 mm, was coated with fine particles containing a drug called budesonide, a steroid used to treat IBD. Eosinophilic esophagitis..

When the drug-containing particles were deposited on the tissue, the researchers contracted the balloon, flattened the needle, and allowed the stent to be removed endoscopically. The process took only a few minutes, and the particles stayed in the tissue, gradually releasing budesonide for about a week.

Depending on the composition of the particles, it can be adjusted to release the drug over a longer period of time, Traverso says. This eliminates the need for the patient to take the medication himself and allows the patient to receive the medication on a regular basis with a temporary stent insertion, making it easier to keep the patient on the correct medication schedule. It also avoids side effects that can occur with systemic drug administration.

Researchers have also shown that stents can be delivered to blood vessels and blood vessels. AirwayThey are currently working on offering other types of drugs and scaling up the manufacturing process, eventually Stent In the patient.

Resume and regenerate: Exosome-coated stents heal vascular damage and repair damaged tissue

For more information:
Kirigami-inspired stents for sustained local delivery of therapeutic agents, Nature Materials (2021). DOI: 10.1038 / s41563-021-01031-1 ,

Quote: Paper-cutting art-inspired tents are from the gastrointestinal tract (2021) obtained on June 14, 2021 from https: // The medicine can be delivered on June 14, 2014 gi.html

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Inspired by paper-cutting art, stents can deliver medicine to the gastrointestinal tract

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