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Long-term suppression of hepatitis B in HIV patients may reduce the risk of cancer

Electron micrograph of hepatitis B virus.Credit: US Centers for Disease Control and Prevention

According to a study by the University of Pennsylvania Perelman School of Medicine, the risk of hepatocellular carcinoma (HCC) (primary liver cancer) is higher in patients infected with HIV, but even higher in patients with HIV and detectable hepatitis B. Suppressing detectable hepatitis B infection using antiretroviral therapy among HIV and hepatitis B participants reduced the risk of developing HCC by 58%. These findings indicate that the best care for individuals with HIV and detectable hepatitis B includes sustained hepatitis B suppression with antiretroviral therapy to reduce the risk of developing HCC. Suggests.The study is published in the journal Hepatology..

HCC affects about 25,000 people each year in the United States and is considered a highly aggressive type of cancer. Internationally and in the United States, chronic hepatitis B is a major cause of HCC through direct and indirect effects on the liver. In addition, chronic hepatitis B is common in patients infected with HIV.

To study the predictors of HCC in people co-infected with HIV and chronic hepatitis B, researchers used data from the North American AIDS Cohort Collaboration on research and design, including 20 years of health information. The study population included data from more than 8,000 people who were co-infected with HIV and chronic hepatitis B. People with HIV and hepatitis B were more likely to develop HCC than those with both viruses suppressed. Antiretroviral treatment of chronic hepatitis B reduces the risk of developing HCC, suppresses hepatitis B viremia to undetectable levels, and significantly increases the risk if viral suppression lasts for at least a year. It has dropped.

“Most HIV providers do not actually monitor hepatitis B viral load on a regular basis, even during antiretroviral treatment,” said Penmedison, an associate professor of medicine and epidemiology. Vincent Lo Re III, MD, MSCE said. “Our data highlight the importance of regular assessment of hepatitis B viral load during antiretroviral therapy and achievement of hepatitis B suppression in people with co-infection of HIV and chronic hepatitis B. In addition, maintaining adherence can be a challenge for certain patients, depending on their overall health and other factors. “This study maximizes the importance of testing and regular care for co-infected persons with HIV and chronic hepatitis B, and antiretroviral adherence for co-infected persons to achieve hepatitis B virus suppression. Emphasizes the value of programs and strategies that help. “

Coinfection with heavy alcohol use and hepatitis C is also associated with an increased risk of HCC, according to Dr. Lore and his team, including Dr. H. Ninakim, MD, an associate professor of medicine at the University of Washington. Was there. People with co-infection of HIV and chronic hepatitis B. The authors of the study found that reducing excessive drinking and using direct-acting antiviral therapies targeting chronic hepatitis C infection may also help reduce the risk of liver cancer in double-infected individuals. I advise you to have one.


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For more information:
H. Nina Kim et al, Risk of hepatocellular carcinoma with hepatitis B viremia in people co-infected with HIV / hepatitis B virus in North America, Hepatology (2021). DOI: 10.1002 / hep.31839

Courtesy of Perelman School of Medicine, University of Pennsylvania

Quote: Long-term suppression of hepatitis B in HIV patients may reduce the risk of cancer (2021, May 21). https: //medicalxpress.com/news/2021-05-long-term-suppression-hepatitis-obtained from patients on May 21, 2021-hiv.html

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Long-term suppression of hepatitis B in HIV patients may reduce the risk of cancer

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