Low cost sensor quickly detects wound infections

Credits: University of Strathclyde, Glasgow

Low-cost screen-printed carbon sensors are used to quickly detect bacteria commonly found in wounds and may pave the way for real-time medical devices.

A study conducted by the University of Strathclyde and NHS Ayrshire & Arran used a highly sensitive portable electrochemical sensor. Clinical sample Within 30 minutes, it’s much faster than the clinical tests in current hospitals.

Detection of infections in clinical practice can be costly, and gold standard laboratory methods for detecting wound infections and identifying bacteria typically take at least 48 hours.

Measured sample

In collaboration with NHS Ayrshire & Arran clinicians, we collected bandages and swabs from patients with diabetes-related foot ulcers at University Hospital Ayr. These samples were then measured at the University of Strathclyde using a new sensor. This revealed that the presence of bacterial infections could be detected quickly.

In the preparatory work that led to this Clinical trials The sensor was used to detect Proteus mirabilis. scratch.. This organism, commonly found in the human gastrointestinal tract, forms part of the body’s normal microbial flora, but can cause illness in people with impaired immune systems and wounds.

A peer-reviewed study that won the Best Paper Award at the annual World Congress on Electrical Engineering and Computer Systems Science in July described real-time electrochemical detection of pathogens and laboratory trials one hour after sample inoculation. Detected proliferation in.

The electrochemical method adopted creates a spectrum formed by measuring the electrical “impedance” of a sample over a wide range of electrical signal frequencies and measuring how current flows through the bacterial layer at each frequency. To do. The time course of these spectra can be investigated to provide information on the microbiological content of the sample. This and a unique mathematical approach to studying spectra have patented this method.

Patient welfare

Health-related infections (HAIs) are a significant threat to the well-being of patients, resulting in increased treatment time, costs, and illness. Wound infection is a common form of HAI.

A study published by the Scottish Government in June, involving Strathclyde, suggested that 1% of patients develop nosocomial infections (HAIs) and NHS Scotland costs more than £ 46 million annually.

Researchers believe that this technology could be incorporated into a cost-effective, real-time wound monitoring device that can detect infections quickly. This can significantly reduce the time it takes to detect and identify wound infections in the clinical setting.

Aiden Hannah, a biomedical engineering researcher at the university who conducted this research, said: Detection using label-free screen-printed carbon electrodes.

“The ability of low-cost sensors to quickly detect the presence of infection in clinical wound samples highlights the potential for adoption in point-of-care infection monitoring devices. Real-time monitoring of infection status enables early adoption. Intervention is possible and improved. Prognosis. “

Diabetic ulcer

Professor Andrew Collier, a consultant diabetic specialist at NHS Ayrshire & Arran, participated in a study with senior foot ulcer Danielle Main, saying, “Unfortunately, diabetic foot ulcers are common and the lifetime risk of ulcers is about 15-25. %is.

“Infections are common and can lead to amputation of the lower extremities if not treated early and aggressively. Early detection and proper treatment of the infection significantly reduces the risk of amputation, 3 in 4 people. Amputation of people can be prevented.

“Early detection infection What is demonstrated in this study will have a significant impact on both individuals with diabetic foot ulcers and NHS resources. “

The study was published in Minutes of the 7th World Congress on Electrical Engineering and Computer Systems and Science..

A biosensor embedded in the bandage can monitor diabetic foot wounds to prevent amputation

For more information:
Aiden J Hannah et al, Rapid detection of wound pathogen Proteus mirabilis using disposable electrochemical sensors, Minutes of the 7th World Congress on Electrical Engineering and Computer Systems and Science (2021). DOI: 10.11159 / icbes21.105

Quote: Low cost sensors for wounds obtained on 9/2021 from https: // (2021, 9) Quickly detect infections (9th of March)

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Low cost sensor quickly detects wound infections

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