Map of mouse brain metabolism in aging

Screenshots of data from the mouse brain metabolomics atlas show the distribution of adenosine in the brain region with age. This resource helps other scientists interpret the results and develop new research. Credit: UC Davis

The first atlas of metabolites in the mouse brain was published by a team led by researchers at the University of California, Davis. The dataset contains 1,547 different molecules across 10 brain regions of male and female laboratory mice, from adolescence to adulthood to old age.The work will be released on October 15th Nature Communications. The complete dataset is published at.

“This is the largest metabolome analysis available in the brain worldwide. It covers 1,547 identified metabolites and is an energy, neurotransmitter, or Complex lipids In the brain. ” Professor Oliver Fiehn, director of the West Coast Metabolomics Center at the University of California, Davis Genome Center and the lead author of the treatise, said.

Metabolomics is the study of chemical fingerprints of metabolism in living cells. It uses advanced high-throughput technology to isolate and identify all the different chemicals or metabolites that are present in a cell, tissue, or organ at a particular time. In addition to genomics, transcriptomics, and proteomics, these technologies give scientists a better understanding of what is happening inside cells and tissues.

Postdoctoral researchers Jun Ding, Fiehn and colleagues sampled 3-week-old (adolescent), 16-week-old (early adult), 59-week-old (middle-aged), and 92-week-old (old-aged) mice. They examined 10 separate brain regions with different functions. The new atlas can be used to better understand these various features, Finn said.

The results show that the brain metabolome makes a clear distinction between large brain regions, such as the brain stem, which control important functions such as breathing and blood pressure, and the cerebrum, which controls movement, speech, and thinking. In addition, specific sections showed high levels of metabolites associated with specific receptors, such as adenosine, ceramides, and phospholipid ethers.

They found no significant metabolic differences between male and female mice in the brain.

Aged brain metabolome

When the team compared animals of different ages, they found that, overall, adult mice showed the greatest metabolic differences between brain sections. Regional differences were less in adolescence and much less in very old ages.

“At a very old age, the energy function seems inefficient, Myelin sheath Anything that surrounds the axons or wires in the brain changes composition, “Feen said.

Lipid molecules have shown a significant difference, especially with aging and overall Brain region.. These lipids deserve specific research to determine how they are associated with changes in brain function such as signal transduction.

At a very old age, the response system to oxidative stress becomes very active, but proteins begin to break down into peptides at an increased rate, he said. These changes are reflected in the metabolome.

This work was carried out in collaboration with the Mouse Biology Program at the University of California, Davis, led by Professor Kentroid.

“This groundbreaking paper underscores its power as a model to accelerate understanding of laboratory mice. brain Metabolism, especially including humans, “he said.

Scientists identify new differences between men and women in age-related changes in brain stem cells

For more information:
Jun Ding et al, Metabolome Atlas of Aged Mouse Brain, Nature Communications (2021). DOI: 10.1038 / s41467-021-26310-y

Quote: Https: // of aging (October 15, 2021) mouse brain metabolism obtained on October 15, 2021 map

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Map of mouse brain metabolism in aging

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