Treatment of obese mice with a cytokine known as TSLP significantly reduced abdominal fat and body weight compared to controls, according to a new study published Thursday. Chemistry From a researcher at the University of Pennsylvania’s Perelman School of Medicine. Unexpectedly, fat loss was not associated with reduced food intake or increased metabolism. Instead, researchers have found that TSLP stimulates the immune system to release lipids through the sebaceous glands, which produce oil in the skin.
“This was a completely unexpected discovery, but we have shown that fat loss can be achieved by secreting calories from the skin in the form of energy-rich sebum,” said Principal Investigator Taku Kamibayashi, MD. Said. Professor of Pathology and Laboratory Medicine, University of Pennsylvania. He led the research with Dr. Ruth Choa, a 4th grade medical student. “We believe that we are the first group to show a non-hormonal way to induce this process, emphasizing the unexpected role of the body. Immune system.. “
The discovery of animal models supports the possibility that increasing sebum production through the immune system is a strategy for treating obesity in people, Kamibayashi said.
Thymic stroma phosphopoietin (TSLP) is a cytokine (a type of immune system protein) involved in asthma and other allergic diseases. The Kamibayashi research group is investigating the expanded role of this cytokine, which activates type 2 immune cells and expands T-regulatory cells. Previous studies have shown that these cells can regulate energy metabolism, so researchers have found that treating overweight mice with TSLP stimulates the immune response and some of the harmful effects of obesity. I predicted that it could be counteracted.
“Initially, I didn’t think that TSLP would affect obesity itself. What we wanted to know was whether TSLP could affect insulin resistance,” Kamibayashi said. Told. “We thought that cytokines could correct type 2 diabetes without actually losing weight in mice.”
Researchers injected to test the effect of TSLP on type 2 diabetes Obese mouse With viral vectors that increase TSLP levels in their bodies. Four weeks later, the researchers found that TSLP not only affected the risk of diabetes, but actually reversed obesity in mice fed a high-fat diet.While Control group As they continued to gain weight, TSLP-treated mice lost weight from 45 grams to healthy 25 grams in just 28 days on average.
Most surprisingly, mice treated with TSLP also reduced visceral fat mass. Visceral fat is white fat that accumulates in the abdomen around major organs and can increase the risk of diabetes, heart disease, and stroke. These mice also experienced improved blood glucose and fasting insulin levels, and a reduced risk of fatty liver disease.
Given the dramatic consequences, Kamibayashi assumed that TSLP made mice sick and reduced their appetite. However, after further testing, his group found that mice treated with TSLP actually ate 20-30% more, similar energy expenditure, basal metabolic rate, and activity when compared to untreated mice. I found that I have a level.
To explain Weight loss, Kamibayashi remembered a small observation that he had previously ignored. “When I looked at the coats of mice treated with TSLP, I noticed that they were shining in the light. I always knew exactly which mouse was treated because it was so shining. Also, “he said.
Mr. Kamibayashi considered a tremendous idea. Was their greasy hair a sign that mice were “sweating” fat from their skin?
To test the theory, researchers shaved the TSLP-treated one mouse Then the control and then the oil was extracted from the fur. They found that Kambayashi’s hypothesis was correct: shiny fur contained sebum-specific lipids. Sebum is a high-calorie substance produced by the sebum cells of the sebaceous glands (highly specialized epithelial cells) that help form the skin barrier. This confirms that the release of oil from the skin is responsible for the loss of fat by TSLP.
To determine if TSLP could potentially play a role in controlling human oil secretion, researchers then examined a panel of TSLP and 18 sebaceous gland-related genes in publicly available datasets. rice field. This revealed that TSLP expression was significantly and positively correlated with sebaceous gland gene expression in healthy human skin.
In humans, shifting sebum release to “high gear” can lead to “fat sweating” and weight loss, the authors of the study write. Kamibayashi’s group is planning further research to test this hypothesis.
“I don’t think you can control your weight naturally by regulating sebum production, but it can hijack the process to increase sebum production and cause fat loss. This can lead to obesity and lipid disorders. It can lead to new therapeutic interventions that reverse. ”
Thymic stroma phosphopoietin induces fat loss through hypersecretion of sebum, Chemistry (2021). DOI: 10.1126 / science.abd2893
Quote: Mice treated with this cytokine were obtained from https://medicalxpress.com/news/2021-07-mice-cytokine-weight-fat.html on July 29, 2021 as “sweat” fat (2021). July 29, 2014) to lose weight
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Mice treated with this cytokine lose weight by “sweating” fat
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