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Microneedles penetrating biofilm for more effective topical delivery of antibiotics to infected wounds

Rahim Rahimi’s flexible biodegradable microneedle array contains calcium peroxide. Microneedles penetrate the wound biofilm layer, oxygenate the tissue, and deliver drugs to effectively eradicate the wound biofilm infection. Credit: Purdue University / Vincent Walter

Purdue University engineers’ patent-pending inventions have the potential to improve the quality of life of millions of people suffering from diabetic foot ulcer.

Rahim Rahimi, an assistant professor at the Faculty of Materials Engineering, has developed a flexible polymer composite. Microneedle An array that can overcome the physicochemical bacterial biofilm present in chronic non-healing wounds and deliver both oxygen and fungicides simultaneously.The results are published in ACS Applied Biomaterial..

“Biofilms act as shields and prevent antibiotics from reaching infected cells and tissues,” says Rahimi. “When these microneedles penetrate the shield, they absorb and dissolve the underlying fluid, delivering antibiotics directly to the ulcerated cells and tissues.”

Rahimi said the traditional way to bypass biofilms is for doctors to strip the biofilms, which is painful for the patient and does not distinguish between unhealthy ones. Organization From a healthy organization.

“Microneedles are not long enough to touch, so they do not cause pain. Nerve endings “In this published study, the team evaluated microneedles in an Exvivo porcine wound model. In less than five minutes, the microneedles were dissolved, antibiotics were administered, and patches were removed. . “

Credit: Purdue University

Lack of proper treatment for infected ulcers can lead to bacterial and septicemia. As a result, chronic wounds are one of the leading causes of limb amputation.

The next step in developing microneedles beyond the proof-of-concept stage is to find a partner to perform human testing. Rahimi has disclosed the innovation to the Purdue Research Foundation Office of Technology Commercialization. OTC Patent application About intellectual property. Innovation is available for licensing.


Wearable and portable inventions provide options for treating antibiotic-resistant infections


For more information:
Ian Woodhouse et al, Flexible Microneedle Array Patch for Chronic Wound Oxygenation and Biofilm Eradication, ACS Applied Biomaterial (2021). DOI: 10.1021 / acsabm.1c00087

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Purdue University

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Microneedles penetrating biofilm for more effective topical delivery of antibiotics to infected wounds

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