More common adenovirus type 4 infection than thought, by extensive systematic review

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A new study by scientists at Duke-NUS Medical School found that human adenovirus type 4 (HAdV-E4) infection (which was long thought to circulate only among US military populations) increased in the general population worldwide. I found out that I was doing it. In a review of 144 studies, the team reported more than 24,500 HAdV-E4 infections from all geographic regions of the world except Central America and the Caribbean between 1960 and 2020, with 11.5% of the outbreaks being the general population. I found that it is in. They emphasize that outbreaks have been on an upward trajectory since the first such infections were reported in the 1970s, calling for continued investment in HAdV-E4 vaccine development. ..

Discovered in 1953, human adenovirus type 4 (HAdV-E4) is one of more than 100 types of adenovirus circulating in humans, most commonly causing infections of the respiratory tract and eyes. When it was first discovered, the virus appeared to be primarily confined to US military recruits who lived in crowded areas and experienced increased stress during military training. Infection was rarely detected in the general population.

Today, HAdV-E4 is recognized as a re-emerging infectious disease because it is increasingly reported among the general public in the United States and internationally. Deaths associated with HAdV-E4 are rare, but have been reported in the United States, China, and Singapore.

“Recognizing the potential for increasing clinical importance of this HAdV genotype, we sought to epidemiologically study the global distribution of clinical HAdV-E4 infections over time,” said Duke-NUS Emerging Infectious Diseases. Dr. Kristen Coleman, Senior Researcher in Infectious Diseases (EID), said. ) Program and lead author of this study.

Results of research published in Clinical infectionsReveals that HAdV-E4 infection in the general population was first recorded in the 1970s and 92 cases were reported in the scientific literature. The number of reported cases surged to 444 in the 1980s, then increased every 10 years, and nearly 800 cases were reported in the 2010s.

This increase is consistent with recent evolutionary changes identified in the viral genome, which may have allowed the virus to adapt better to humans and enhance circulation outside military personnel.

“This is an important example of how molecular evolution of the virus can lead to clinically significant persistent human infections. This study requires continued investment and development of vaccines for HAdV-E4. We also emphasize sex, “said Professor Gregory Gray of Duke-NUS. The corresponding author of this study, the EID program.

“Adenovirus circulates widely among humans and has caused many disease outbreaks, especially in hospitals and military installations. In this review, EID experts commented on genetic evolution and how this affects the clinical effects of the virus. It provides new insights into how it affects them. Their insights provide a solid foundation for improving public health readiness against potential adenovirus outbreaks in high-risk populations. ” Professor Patrick Casey, Senior Vice Dean of Research at NUS, said.

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For more information:
Kristen K. Coleman, Emily R. Robie, Anfal Abdelgadir, Arthi S. Kozhumam, Raquel A. Binder, and Gregory C. Gray (2021). 60 Years Review of Human Adenovirus Type 4 Infection: Increased Transmission Among Civilians is a Concern. Clinical infections, / cid / advance-a… / cid / ciab146 / 6157989

Duke-Provided by NUS Medical College

Quote: More common adenovirus type 4 infections than thought, the discovery of a large systematic review (2021, March 10), https: // Obtained from -infections-common-thought-large on March 10, 2021-scale.html

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More common adenovirus type 4 infection than thought, by extensive systematic review

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