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“Nanozyme” therapy prevents the accumulation of harmful plaque

A new study shows that the combination of iron oxide nanoparticles and hydrogen peroxide provides an accurately targeted treatment for killing harmful oral bacteria, breaking down plaque, and even diagnosing harmful oral biofilms. You can get it.Credits: Courtesy of Research Authors

Increasing evidence indicates an association between iron deficiency anemia and severe caries. It is unclear whether the relationship is correlated or the cause, but both conditions are associated with a poor diet and are common in people living in poor environments and in underlying medical conditions.


A study currently conducted by the University of Pennsylvania in collaboration with the University of Indiana suggests that FDA-approved treatments for iron deficiency anemia are promising for the treatment, prevention, and even diagnosis of tooth rot. .. A treatment that is a combination of hydrogen peroxide and a solution containing iron oxide nanoparticles called fermoxitor was placed in a denture-like instrument and applied to the actual tooth enamel worn by the study subject. ..

Studies published in the journal Nano letterApplying fermoxitor, which activates hydrogen peroxide contained in follow-up rinses, twice a day significantly reduces the accumulation of harmful plaque and has a targeting effect on bacteria that are the main cause of tooth decay. I found that there is. These types of nanoparticles with enzymatic-like properties, sometimes known as “nanozymes,” are increasingly being explored for their potential in biomedical and environmental applications.

“This approach turned out to be accurate and effective,” said Hyun (Michel) Koo, a professor of dentistry at the University of Pennsylvania. “It destroys biofilms, especially those formed by Streptococcus mutans, Caused tooth decay and also reduced the degree of enamel rot. This is the first study known to have been done in the clinical setting to demonstrate the therapeutic value of nanozymes for infectious diseases. “

This work is an extension of the paper published in 2018. Nature CommunicationsKuu and colleagues, including David Cormode of the University of Pennsylvania School of Medicine, have shown that iron oxide nanoparticles-hydrogen peroxide treatment can prevent biofilm buildup and tooth decay. Experimental model And animal models.

In current research, scientists wanted to take the next logical step of working in humans. In a randomized study, 15 participants were asked to use a removable denture-like device fitted with real tooth enamel. This method was developed and extensively tested by Domenick T. Zero of Indiana University, the co-author of the current paper.

Research participants applied a solution containing sugar to the appliance four times a day to mimic the high-sugar diets and light meals consumed in daily life. Participants were asked to rinse the equipment twice daily, rather than polishing the enamel specimens. Participants were divided into three groups. One used fermoxidol followed by a hydrogen peroxide rinse, one used a solution that provided the inert component of fermoxidol, and the third used water only.

Fourteen days later, the researchers analyzed the biofilm that had accumulated on the enamel specimen.They found that experimental treatment strongly reduced the growth of biofilms, including: S. mutans And this bacterium can be killed with high specificity. Other symbiotic bacteria commonly found in the mouth were unaffected by fermoxidol-hydrogen peroxide therapy.

The results and safety of the approach were supported by previous studies showing that iron oxide nanoparticles do not bind to the mucosal tissue of the mouth and cause cytotoxicity or alterations in the oral microflora of animal models.

“This treatment is unlikely to have harmful and untargeted effects,” says Koo.

There are three reasons for this accuracy. Hydrogen peroxide-catalyzed reactions occur only in highly acidic environments, such as when the bacteria that cause tooth decay are present and active. This process breaks down the sticky matrix of carbohydrates, breaks down biofilms, and exposes microorganisms.And fermoxitor can specifically bind to the above receptors S. mutans Cell membrane, facilitating its killing..

At the final stage of the study, researchers added a marker that turned blue when exposed to reactive oxygen species. hydrogen peroxide By fermoxidol nanoparticles. And in fact, the team found that the intensity of the blue label was compatible with acidic biofilms, including: S. mutans..

For this “detection” feature, Koo states: Experimental treatment It could be a “ceranostick”, a drug that can be used for both diagnosis and treatment of the condition. “You can use it at home,” says Koo. “It can be washed away to see how much plaque is causing tooth decay and then treated with a solution or a follow-up treatment with a dentist.”


Dental plaque is not comparable to catalytic nanoparticles


For more information:
Yuan Liu et al, Fermoxidol nanoparticles target biofilms that cause tooth decay in the human mouth Nano letter (2021). DOI: 10.1021 / acs.nanolett.1c02702

Quote: “Nanozyme” therapy for harmful plaque obtained on October 26, 2021 from https: //phys.org/news/2021-10-nanozyme-therapy-dental-plaque-build-up.html Prevents accumulation (October 26, 2021)

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“Nanozyme” therapy prevents the accumulation of harmful plaque

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