New devices for exploratory imaging allow about 1,000 times more access to brain tissue

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Science is investigating neural activity in the brain in a variety of applications, from innovative treatments for brain-related injuries and illnesses to computational learning architectures in artificial intelligence and deep neural networks.

The research team has discovered that researchers can develop tools that allow them to see more of the brains of living mice and advance research into the neural circuit mechanisms that form the behaviors that underlie the human brain. .. This tool overcomes the drawbacks of traditional brain probes, which are limited in their ability to image neurons of interest due to the small amount of tissue that can be accessed.

The innovation is to insert an imaging probe with side-view capabilities into a previously inserted optically matched channel (ultra-thin wall glass capillary) to transform deep brain imaging into endoscopic imaging.The operator can freely rotate the probe to display various images. Brain region, Get a 360 degree view for imaging along the overall length of the inserted probe. With this high-capacity imaging, an increase of about 1,000 times is possible. Organization Access volume compared to what is available for imaging at the tip of a typical miniature imaging probe.

A system called COMPACT (Clear Optically Matched Panorama Access Channel Technology) advances the use of high-resolution optical imaging in the living brain to investigate the function and adaptability of the neural circuits that support behavior. increase. The long-term goal is to transform the study and understanding of deep mammalian brain function through close collaboration with neuroscientists.

The study is published at Nature Methods..

A small implantable tool for light sheet imaging of brain activity

For more information:
Bowen Wei et al, Clear Optically Matched Panorama Access Channel Technology (COMPACT) for Massive Deep Brain Imaging, Nature Methods (2021). DOI: 10.1038 / s41592-021-01230-3

Provided by
Purdue University

Quote: New device for exploratory imaging is available from on September 20, 2021 for brain tissue (2021, 9). It enables about 1,000 times more access to (20th of March). html

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New devices for exploratory imaging allow about 1,000 times more access to brain tissue

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