New discoveries in the pathology of atherosclerosis

Atherosclerosis is a condition that affects the cardiovascular system. If atherosclerosis occurs in the coronary arteries (which supply the heart), the result can be angina or, in the worst case, a heart attack. Credit: Wikipedia / CC BY 3.0

New discoveries show how the progression of atherosclerosis is affected by a combination of hypertension and changes in arterial stiffness.

Research published in Science Advances Discover the importance of pressure detection in combination with rigidityWhen deciding the behavior of Vascular smooth muscle cells.. This study further identifies molecular pathways associated with “mechanical sensing” in cells and tissues.

Dr. Thomas Iskratsch of Queen Mary University of London, co-author of this paper, said: Severe illnessIt can lead to heart attacks, angina, and heart failure, among others. Currently, there is no effective treatment. Common risk factors are high blood pressure and age-related changes in arterial wall stiffness. ”

“To identify potential new strategies targeting this disease, our study explores the combined role of these” mechanical “stimuli, pressures, and rigidity on arterial smooth muscle cells. Was aimed at. These cells are present in the arterial wall, but the progression of atherosclerosis. ”

Researchers have studied how both hypertension and changes in arterial wall stiffness are perceived by vascular smooth muscle cells in the arterial wall.

Overall, the arterial wall becomes stiff, but surprisingly, the initial thickening of the arterial wall leads to a softer environment on a cellular scale, stimulating smooth muscle cells with hypertension to change behavior and contract from contractile to contractile. Discovered switching to sex “synthetic” phenotype. This allows cells to further decompose and reconstruct the environment, further softening the progression of the disease and making it spiral.

They also found that different perceptions of both pressure and soft environment acted upon. Molecular pathway However, it was acting on the same effector molecule.

“The interaction of different mechanical pathways is unknown, and it was surprising that the combination of soft environment and pressure had this strong effect,” said Dr. Iscratch.

So far, there is no efficient cure for atherosclerosis.Blood vessels Smooth muscle cells Play an important role in Disease progression Switching between those phenotypes is especially an important step. Follow-up studies will consider how the findings can be used in therapeutic approaches.

Study examines elevated arterial plaque

For more information:
Pamela Swiatlowska et al, pressure and stiffness sensing together regulate vascular smooth muscle cell phenotypic switching, Science Advances (2022). DOI: 10.1126 / sciadv.abm3471

Quote: Effects of hypertension and aging on arterial walls: New discoveries on the pathology of atherosclerosis (April 29, 2022) https: // Obtained April 29, 2022 from impact-artery-walls.html

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New discoveries in the pathology of atherosclerosis

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