New drug combinations have emerged as “promising candidates” for on-demand contraceptives, suggesting preliminary studies published online in the journal. BMJ Sexual & Reproductive Health..
The combination of ulipristal acetate, which is currently used as an emergency contraceptive, and the COX-2 inhibitor meloxicam, a non-steroidal anti-inflammatory drug, has the largest pregnancy and is known as peak pregnancy.
The day immediately before ovulation, known as the luteal surge, is the most difficult day to prevent ovulation and the day when egg fertilization is most likely to occur.
Ulipristal acetate interferes with ovulation, but only if taken before the onset of luteal surge. Drugs such as COX-2 inhibitors, on the other hand, can interfere with ovulation even after the luteal surge begins.
Therefore, researchers aim to identify potential candidates for potentially highly effective on-demand contraceptives for use before and after sex as needed, or for emergencies, for both drugs. I wanted to find out if the combination works with the best fertility.
10 healthy people woman The study included ages 18-35, all of whom had regular periods.
Each woman was monitored by two people Menstrual cycle: Baseline cycle. Participants received a combination of ulipristal acetate 30 mg and meloxicam 30 mg before and after the luteal phase surge to identify a normal ovulation pattern and treatment cycle.
Ultrasound scans and major hormone measurements were taken to determine if luteal surges and ovulation occurred or were interrupted. Nine women completed both the baseline and treatment cycle and were included in the final analysis.
Ovulation was interrupted in 6 women in the treatment cycle. Most (89%, 8) met some criteria for incomplete ovulation.The treatment cycle was about 3 days long: this cycle Length confusion is especially important for those who may be using fertility perception methods, researchers explain.
Since this is an exploratory study of only nine women, they emphasize the need for further research on the safety and efficacy of more women.
However, they suggest that the results are promising. This is because the combination of ulipristal acetate and meloxicam can interfere with ovulation at the highest risk of conception, making it a “promising candidate for evaluation as a perioral oral contraceptive.”
They add: “Comparing the ovulation disorder rate in our study with previous studies on which our protocol is based, [ulipristal acetate] And meloxicam was destroyed ovulation At each stage of the fertile window, more than any other drug previously studied. ”
Findings also suggest adding meloxicam to ulipristal acetate They say it may increase the effectiveness of the latter as an emergency contraceptive.
Potential Candidates for Oral Contraceptives: Evaluation of Ulipristal Acetate and Cyclooxygenase-2 Inhibitors for Ovulation Disorders, BMJ Sexual & Reproductive Health (2022). DOI: 10.1136 / bmjsrh-2021-201446
British Medical Journal
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New on-demand contraceptive combo “promising candidates”
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