New population-based studies show an increased risk of dementia and depression in RA

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In a study presented at the 2022 EULAR conference, Dr. Jens Christian Pedersen and colleagues used data from the DANBIO registry to kill all causes of depression in patients with rheumatoid arthritis (RA). I explained the risks.

This group used the first entry on the antidepressant prescription as a substitute for depression. Of the 11,071 RA patients, 10% met the antidepressant prescription. According to the analysis, depression was associated with a more than 6-fold increased risk of death in patients with RA.

Increasing evidence suggests that people with RA are at increased risk of developing the disease dementia.. However, the incidence of dementia in RA patients has declined in recent years. It is unclear whether this reflects a broader trend in the incidence of dementia, whether treatment advances lead to better control of RA, or other factors. Dr. Elena Myasoedova Risk factor In the case of accidental dementia in a large starting cohort of RA patients.

An important finding was that, among other risk factors, clinically active RA was associated with an increased risk of dementia. The cumulative incidence of dementia increased by 2-3% every 5 years after the diagnosis of RA, and elderly people with RA incidence were consistently associated with the risk of dementia.

The presence of rheumatoid nodules, large joint swelling, hypertension, heart failure, and depression at baseline or in the first year after RA occurred was significantly associated with the risk of dementia.Swelling of large joints, cardiovascular or Cerebrovascular accident (especially heart failure When Ischemic stroke), Anxiety and depression have always increased the risk of dementia. Studies are underway to evaluate the role of systemic inflammation and its interaction with other risk factors for the risk of cognitive decline in RA patients.

Dr. Yeonghee Eun also shared data on the association between dementia and RA based on a study in a large population-based cohort.

The results showed that RA patients had a 1.2-fold higher risk of dementia than controls. This included both Alzheimer’s disease and vascular dementia. A stratified analysis by age, gender, lifestyle factors, and comorbidity showed a consistent association between RA and dementia. The authors state that proper assessment of dementia is necessary when: Cognitive dysfunction Occurs in RA patients.

Studies find that risk factors for dementia may vary with age

Provided by the European Alliance of Associations for Rheumatology (EULAR)

Quote: The new population-based study was obtained from on June 3, 2022 RA (June 3, 2022). ) Shows an increased risk of dementia and depression. html

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New population-based studies show an increased risk of dementia and depression in RA

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