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New research helps explain how inflammation increases the vulnerability of COVID-19

Christiane Miranda Franca, DDS, MS, Ph.D. , Associate Professor of Restorative Dentistry at OHSU School of Dentistry, and her colleagues created two models to simulate large and small capillaries. Here, she shows her tissue response in a study of the body’s susceptibility to inflammation and COVID. Credits: OHSU / Christine Torres Hicks

New studies suggest possible explanations for why people with diabetes, asthma, and other conditions with chronic inflammation are more susceptible to coronavirus and are more likely to experience COVID-19.

Preprinted studies submitted to scientific journals but not peer-reviewed by other researchers cause COVID-19 to infect more cells in laboratory-generated capillaries or small blood vessels. I found a virus. Treated with an inflammatory agent.

To carry out this study, researchers at Oregon Health & Science University designed capillaries with small transparent devices etched in small channels. Scientists filled these channels with cultures of two types of cells, stem cells and endothelial cells. Endothelial cells line the inside of blood vessels and capillaries and are also involved in the body’s inflammatory response. Stem cells It has a unique ability to develop into other cell types. Inside a transparent device, stem cells naturally develop into pericytes, wrap around the endothelium, and help control blood flow in blood vessels and capillaries.

Researchers were inspired by a research approach known as Organ-on-a-chip, which describes their setup as a vascular on-chip and creates microscopic organ models for laboratory research. This study is based on previous studies showing that pericytes are involved in COVID-19 symptoms such as myocarditis, cognitive impairment, and long COVID.

“This study is working to elucidate the internal mechanics of COVID, so we will add another element to the puzzle,” said the lead researcher, Associate Professor of Biomaterials and Biomechanics at Oregon Health & Science University. Authors Luiz Bertassoni, DDS, Ph.D. Says. Associate Professor of Biomedical Engineering, Faculty of Dentistry, and OHSU School of Medicine and OHSU Knight Cancer Institute.

The lead author of this study, Christiane Miranda Franca, DDS, MS, Ph.D. , Associate Professor of Restorative Dentistry at OHSU School of Dentistry, and her colleagues created two models to simulate large and small capillaries. A copy of each model size was treated with an pro-inflammatory chemical known as TNF-α to reproduce inflamed capillaries, or reproduced healthy capillaries without this treatment. Researchers exposed laboratory-generated capillaries to peplomer proteins from the virus that causes COVID-19 and compared tissues under a microscope.

They found quite a lot Spike protein Included with Lab Capillary Treated with an inflammatory agent. The authors hypothesized that chronic inflammatory health conditions such as obesity, diabetes and asthma could be particularly dangerous to pericytes. Researchers suggest that this may help SARS-CoV-2 pass through blood vessels, proliferate, and spread throughout the body.

“Inflammation appears to expose pericytes more to the virus that causes SARS-CoV-2, COVID-19,” Bertassoni said. “Better understanding [of] The vascular mechanism behind this may help find new ways to treat or prevent COVID. “

Further research is needed, but Bertassoni et al. Explain their work as a proof of principle.


Evidence suggests that the SARS-CoV-2 virus attacks brain endothelial cells


For more information:
Inflammation of blood vessels exposes cells around the blood vessels to SARS-CoV-2 infection (2022). 10.1101 / 2022.04.05.487240 www.biorxiv.org/content/10.110… /2022.04.05.487240v1

Quote: New research helps explain how inflammation increases the vulnerability of COVID-19 (April 7, 2022).

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New research helps explain how inflammation increases the vulnerability of COVID-19

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