Potential new drug for incurable vascular dementia

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According to a study partially funded by the British Heart Foundation, drugs already used to treat high blood pressure are the first treatments to address the type of vascular dementia caused by damaged “leaky” small blood vessels in the brain. May be reused as a law and today Clinical Research Journal..

Hypertension is known to be a major risk factor for developing the disease Vascular dementia..But how High blood pressure Compensation for damages Small blood vessels, Narrow and limit them Blood flow It was unknown in a specific area of ​​the brain.Effectiveness of various types of blood pressure dosage It has never been tested directly on these arteries.

Researchers at the University of Manchester are now working with colleagues in the United States to discover that the blood pressure drug amlodipine may help treat or prematurely stop vascular dementia.

They examined blood flow in the brain of mice with hypertension and vascular damage in the brain. Mice treated with amlodipine had better blood flow to more active areas of the brain. Their arteries could widen, allowing more oxygen and nutrients to reach the parts of the brain that needed them most.

The team also discovered for the first time that high blood pressure reduces the activity of a protein called Kir2.1 that resides in cells that line blood vessels, increasing blood flow to active areas of the brain.

Amlodipine has been found to restore Kir2.1 activity and protect the brain from the harmful effects of hypertension. Researchers say the protein could be the target of other drugs in the future, offering potential additional ways to help fight the disease.

The team now wants to test amlodipine as an effective treatment for vascular dementia in humans. If successful, it is the first clinically proven treatment of vascular dementia as a result of microvascular disease and can be used in people with early signs of the condition to prevent further progression.

Dr. Adam Greenstein, senior clinical lecturer at the University of Manchester’s Cardiovascular Sciences, who led the Manchester team, said, “The way vascular dementia develops has remained a mystery, and currently clinically proven treatments are No. The symptoms of vascular dementia are faster than ever, and further research could provide patients with hope to prevent the progression of this life-changing disease. “

Professor Metin Avkiran, Associate Medical Director of The Hart Foundation, said, “Research is the way to better understand this catastrophic disease and find new treatments. This study explores the progression of vascular dementia. It’s an important step in finding a new way to stop it. “

“These new discoveries highlight the major role that high blood pressure plays in the development of the disease and reveal how this happens and may be prevented in the future. Currently to reduce the risk of the disease. The most important thing you can do is keep your blood pressure within a healthy range. You can check your blood pressure for free at your GP or your local pharmacy. ”

Hypertension associated with vascular dementia

For more information:
Shodai Naoya et al., Secondary recovery of functional hyperemia by antihypertensive drug class in hypertension-related cerebrovascular disease, Clinical Research Journal (2021). DOI: 10.1172 / JCI149029

Quote: Potential new drug for refractory vascular dementia (September 15, 2021) from https: // 2021 Obtained on September 15th.

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Potential new drug for incurable vascular dementia

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