Researchers are developing low-cost electroporation devices that can increase global access to anti-cancer drugs

Schematic of the process of pore formation in a phospholipid bilayer after electroporation. Credit: SUTD

Researchers at the Singapore Institute of Technology (SUTD) have developed a microsize gap multi-shot electroporation (M2E) device. This will increase the effectiveness of delivering anti-cancer drugs at low cost around the world.

“One of the goals of the scientific community is to develop a simple, manufacturable, and low-cost method of delivering antineoplastic agents,” said Desmond Loke, an assistant professor at SUTD and principal investigator for the study. ..

A way to increase the prospect of antineoplastic delivery may be by electroporation, a method of applying a very weak electrical pulse to a cell to temporarily puncture the cell membrane. Antineoplastics can be delivered through these holes. The combination of electroporation with anticancer drugs can improve both drug efficacy and accessibility.

Integrated researcher Transparent electrode On devices to enhance visibility of anti-cancer drugs. “The narrow gap between the electrodes allows us to use a few volts to achieve a sufficiently strong electric field instead of the tens of volts applied in traditional electroporation,” says Assistant Professor Loke.This low voltage and the transparency of the electrodes minimize it. Energy consumption Promotes visibility. This avoids unsafe use of the drug and limited imaging of drug transport during drug testing. Both of these are common problems with traditional electroporation systems.

In addition, in chemotherapeutic applications, tumor cells can be made permeable by electroporation, thereby facilitating the uptake of chemotherapeutic agents such as bleomycin and cisplatin.

Researchers have tested M2E devices using anticancer drug-related molecules.With this device, cancer cells time frame 2 hours of molecular uptake, 400% larger than traditional electroporation systems. In addition, it is reusable. Researchers suggest that the M2E system may be used in combination with drugs that are also associated with the treatment of Covid-19.

“The devices developed by SUTD, unlike traditional devices, do not require special components, expensive materials, or complex manufacturing processes. Electroporation “Machine”.

Optimization of the M2E system is currently underway, and researchers predict that it may take several years for the device to complete clinical trials and become more widely available. “We hope that the M2E system can provide a way for significant improvement. cancer drag Allows for more uniform distribution with the delivery process Anti-cancer agent In poorly serviced areas around the world due to lack of resources, “added Assistant Professor Loke.

The study was published in ACS Omega..

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For more information:
Denise Lee et al, ultra-long recovery and low voltage electroporation for living cell monitoring enabled by a micro-sized multi-pulse framework, ACS Omega (2021). DOI: 10.1021 / acsomega.1c04257

Quote: Researchers have obtained an anticancer drug obtained from https: // on February 11, 2022 (February 11, 2022). We are developing a low cost electroporation device that can expand global access to)-access.html

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Researchers are developing low-cost electroporation devices that can increase global access to anti-cancer drugs

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