Researchers are developing new treatments to combat obesity and heart disease

A 3D model of the heart by Dr. Matthew Bramlet. Credit: NIH

An interdisciplinary research team at the University of Texas at San Antonio has succeeded in developing an innovative inhibitor with the potential to combat obesity and prevent heart disease. Francis Yoshimoto, an assistant professor in the Department of Chemistry at the UTSA Faculty of Science, leads a team that has developed an anti-obesity drug that blocks the effects of the enzyme chitochrome P4508B1, which is associated with cholesterol absorption and obesity.

Yoshimoto tested the new drug in collaboration with Jung Eun-hee, an associate professor of the Department of Exercise, Faculty of Health, Community and Policy, UTSA. After designing and synthesizing it, Yoshimoto sent test samples to a laboratory funded by Chung’s National Institutes of Health, where she and her research team contained small amounts of bioactive compounds (plants and certain foods). I am studying the effects of chemical substances and exercise methods.Can be used for treatment obesity And related metabolic disorders.

Their research results were published in the February 2022 issue of the scientific journal. steroid..

“Growing up, I dreamed of helping a family affected by obesity. Heart disease “By developing a small molecule that can be used to combat obesity, a problem found in many families around the world, this dream is now becoming a reality,” said Yoshimoto.

“As an exercise physiologist, I really believe that exercise is the best medicine for fighting non-communicable diseases,” Chung added. “Unfortunately, adherence to exercise is very low and the prevalence of obesity is continuously increasing. We strongly hope to further test Dr. Yoshimoto’s inhibitors based on promising data. . “

UTSA medicines may stop the activity of P4508B1, an enzyme that produces cholic acid in the body. This suppression, in turn, reduces cholesterol absorption.This process may hold the key to obesity-related treatments Metabolic disorders Other diseases related to obesity, such as heart disease and diabetes.

The team’s study included treating mice with inhibitors for 7 days. As a result, blood glucose levels were reduced despite being fed a high-fat, high-sucrose diet without affecting body weight. The results show how P450 8B1 inhibitors can lead to a healthy metabolic profile, which may lead to the development of therapeutic strategies for treating obesity-related insulin resistance. is showing.

The work of Yoshimoto and Chung represents UTSA’s mission to develop solutions to complex challenges that improve social health and welfare. By making medicines that are effective in preventing obesity, we can improve the quality of life around the world.

according to World Health OrganizationIn 2016, 1.9 billion adults worldwide were overweight and 650 million were classified as obese. Near home, one-quarter of deaths in the United States are due to heart disease, the main cause of which is obesity. Locally, 71% of adults are overweight or obese. Recent reports From San Antonio Metropolitan Health District.

“These results show that research in synthetic chemistry can make a significant contribution to the well-being of society by treating obesity and heart disease,” said Yoshimoto.

Scientists Design Protein Blockers to Fight Obesity and Heart Disease

For more information:
Eunhee Chung et al, Synthesis of a rationally designed inhibitor of chitochrome P450 8B1, a therapeutic target for the treatment of obesity, steroid (2021). DOI: 10.1016 / j.steroids.2021.108952

Quote: Researchers found obesity and heart disease (March 2022) obtained from https: // on March 4, 2022. Develop a new cure to fight (4th)

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Researchers are developing new treatments to combat obesity and heart disease

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