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Researchers Develop Newly Redefined Breast Cancer Response Subtypes

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Research scientists and statisticians at the University of California, San Francisco have developed an improved biomarker classification as part of the findings of the I-SPY 2 trial in patients with high-risk breast cancer. The new cancer response subtypes reflect responsiveness to drug treatment and are intended to help clinicians more accurately target treatment.

I-SPY 2 (Investigation of a series of studies to predict therapeutic response by imaging and molecular analysis) Using the multiomics molecular properties of a variety of drugs targeting all tumors and various molecular pathways in the study, I -SPY2 researchers can access relevant datasets to create breast cancer subtypes that match the latest treatments.

Researchers whose findings have recently been published online cancer cellBy combining predictive biomarkers to create responses that predict breast cancer subtypes, we show that these subtypes can be adapted to the most effective and modern treatments. The best subtyping schema incorporates immunity, DNA repair, lumen, and HER2 phenotypes. Assignment of treatments using these response prediction subtypes may improve treatment efficacy and patient outcomes.

Sponsored by QuantumLeapHealthcare Collaborative (QLHC), which manages all collaboration between academic and industry partners, I-SPY 2 has announced that these new subtypes will move forward in the next iteration of the I-SPY 2.2 trial.

Using I-SPY2-990 mRNA / phosphoprotein data resources from approximately 1000 patients who participated in the 10-arm of the I-SPY2 trial, researchers found 27 predictive I-SPY2 eligible bios that led to the development of responses. Markers evaluated-Predictive subtyping schema for prioritizing treatment. Lead authors Denise Wolf, Ph.D. and Christina Yau, Ph.D., both in UCSF, used gene expression, protein levels, and 10 response data. medicine-Arm of the I-SPY2 neoadjuvant study to create new breast cancer subtypes incorporating tumor biology beyond clinical hormone receptor (HR) and HER2 status.

“The use of these response prediction subtypes will guide treatment prioritization, enhance response and revolutionize the way physicians treat patients,” said Dr. Lauravan’t Veer, co-director of UCSF Breast. Says. Chief Scientist in Oncology Program and I-SPY2 Biomarker Research.

The high-risk groups of triple-negative and HER2-negative hormone receptor-positive are divided into three different response prediction subtypes. The HER2-positive group is divided into two reaction prediction subtypes. Researchers have shown that the use of subtype schemas that represent several drug-targetable pathways allows for better classification of tumors and is an improvement over current standard methods. ..

The I-SPY 2 trial is seen as the archetype of a new approach to clinical trials.Instead of the traditional “one drug, one disease” model Drug development, This is a “platform” trial. I-SPY 2 evaluates multiple medicines (or drug combinations) in parallel with the goal of determining which medicine is most effective for different types of breast cancer. I-SPY 2 is designed with an emphasis on efficiency and speed by adopting an “adaptive” statistical model. The results for each patient are used to improve how the investigational drug is assigned to new patients. With that approach, I-SPY 2 can achieve similar results in less time with fewer patients than traditional trials. The goal is to deliver the right medicine to the right patient. These new response prediction subtypes help to better characterize a person’s tumor and then determine if they are likely to respond to a particular treatment, such as immune checkpoint inhibition.

“Patient treatment over the last decade within the I-SPY program has taught us that the standard biomarker tests we use today cannot optimize patient treatment,” said UCSF Breast Co-Director. Laura Esserman, MD, said. She is the director of the Oncology Program and UCSF Breast Care Center, and the Principal Investigator of I-SPY 2. “The entire I-SPY team is really excited to see these results and improve the way treatments are targeted. This is an important advance for patients and the I-SPY model is developing new cancer treatments. It clearly shows that not only can the drug be treated, but the most beneficiary patients can be treated, which means that the drug is more likely to be curative and may not be useful or may add toxicity. It means minimizing the use of some other treatments. “

The I-SPY 2 network prospectively tests the response prediction subtyping schema of I-SPY 2.2. The next version of the I-SPY2 trial incorporates a sequential multi-assignment randomized trial (SMART) scheme to adapt treatment based on individual patients. About biology and reaction.

I-SPY2-990 mRNA / RPPA data resource has been released. “This dataset will be a very valuable resource for the breast. cancer To the research and drug development community, and ultimately to the patient. ”


A novel genomic predictor of the discovered chemical susceptibility of breast cancer


For more information:
Denise M. Wolf et al, Redefining Breast Cancer Subtypes to Guide Treatment Prioritization and Maximize Responses: Predictive Biomarkers Across 10 Cancer Treatments, cancer cell (2022). DOI: 10.1016 / j.ccell.2022.05.005

Quote: Researchers have obtained a newly redefined breast cancer response sub from https://medicalxpress.com/news/2022-06-newly-redefined-breast-cancer-response.html on June 4, 2022. Develop type (June 4, 2022)

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Researchers Develop Newly Redefined Breast Cancer Response Subtypes

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