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Researchers discover a subset of cardiac fibroblasts involved in stressed heart inflammation

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Inflammation is part of the process of weakening the heart and causes heart failure. In response to pressure overload such as high blood pressure, monocytes (a type of white blood cell) enter the heart and become inflammatory macrophages.

Macrophages produce Inflammatory cytokine, This affects the immune system, heart.. CC Motif Chemokine Ligand 2 (CCL2) is known to be a chemokine that facilitates the movement and positioning of monocytes.

The heart is made up of many types of cells, including heart cells. Fibroblast, And smooth muscle cells. However, it is currently unknown which type of cells in the heart produce CCL and attract monocytes in the blood to the heart.

The research team led by Professor Kinya Otsu Cardiac fibroblasts Activated by pressure overload, it attracts monocytes to the heart. They found that cardiac fibroblasts produce CCL2 and that cells can be named inflammatory fibroblasts.

Next, mRNA expression patterns were examined at the single-cell level using so-called single-cell RNA sequencing analysis, and a subset of highly expressed genes in cardiac fibroblasts activated by the transcription factors NF-kB and CCL2 mRNA. I found. In mice that did not express the NF-kB activator IKKb in cardiac fibroblasts, pressure overload did not induce monocyte recruitment and did not induce heart failure.

The adult heart contains many resident cardiac fibroblasts that play an important role in maintaining tissue structure. In response to tissue damage or stress, resident cardiac fibroblasts are activated myofibroblasts, a highly synthesized cell type that induces genes encoding smooth muscle α-actin (ACTA2) and collagen. Go through the transition to. These cells acquire the ability to mediate contraction, migration, proliferation, extracellular matrix refinement, and the development of cardiac fibrosis. Although myofibroblasts have been considered the only phenotype of activated fibroblasts, different subsets of fibroblasts, inflammatory fibroblasts and myofibroblasts, have been reported in arthritis. Pancreatic cancer..

Therefore, the purpose of this study is based on the hypothesis that distinct subsets of inflammatory-related activated fibroblasts play important roles in the recruitment of inflammatory cells, especially monocytes / macrophages, and the regulatory signaling pathways in cardiac inflammation. Was to identify.Pathology heart failure..

The next step in this study is to identify markers for inflammatory fibroblasts, isolate cell populations, characterize cells and regulate their activity.

The study was published in Scientific signaling..


Conversion of scar tissue to myocardium after heart attack


For more information:
Kinya Otsu et al., Activation of NF-κB in cardiac fibroblasts results in the recruitment of inflammatory Ly6Chi monocytes in a pressure-overloaded heart. Scientific signaling (2021). DOI: 10.1126 / scisignal.abe4932

Quote: Researchers found stressed cardiac inflammation obtained on October 14, 2021 from https: //medicalxpress.com/news/2021-10-subset-cardiac-fibroblasts-involved-inflammation.html (2021). October 14) Discovered a subset of cardiac fibroblasts involved

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Researchers discover a subset of cardiac fibroblasts involved in stressed heart inflammation

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