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Researchers [FeS] Clusters function as biological fusions of many proteins involved in the immune response

Credits: Kourosh Ebrahimi

A team of researchers led by Dr. Kurosh Ebrahimi of the Faculty of Cancer Pharmacy will investigate the role of iron sulfide ([FeS]) Clusters and proteins in the immune response to viral infections.


[FeS] Clusters are composed of various stoichiometry of iron (Fe) and sulfur (S) atoms. [2Fe-2S], [4Fe-4S]Also [3Fe-4S]..Iron atom get together It binds to the amino acids cysteine ​​(Cys) or cysteine ​​and histidine (His) in the protein.From the beginning of life on earth [FeS] Clusters have become an important component of the cellular mechanism. In all living things, including humans [FeS] Clusters are present in many cellular proteins and enable them to perform important cellular processes such as respiration, DNA regeneration, and RNA and protein synthesis.

Despite years of research trying to understand the method [FeS] Clusters are synthesized and transported intracellularly. [FeS]Although the proteins it contains work, little research has been done to understand its role. [FeS] Clusters and proteins at the interface of host-virus interactions.

In this study, the team proposes new features for [FeS] Clusters in biology by suggesting that they act as biological “fusions” of many proteins involved in the immune response. When the virus infects cells, the innate immune response produces hydrogen peroxide and nitric oxide. These molecules are highly reactive.They attack Viral protein Genome material blocks the growth of the virus. Their excess can damage the genomic material of cells and cause diseases such as cancer and neurodegeneration.

The [FeS] Clusters can sense and degrade the increase in the amount of these molecules. After that, the activity of many proteins involved in the immune response ceased, hydrogen peroxide And nitric oxide. In summary, [FeS] Clusters control the response of the immune system and protect cells while fighting the virus.

“This article is [FeS] Clusters and proteins Immune response And virus infection. This basic knowledge can help us understand the link between viral infections and inflammation and human illnesses such as cancer and neurodegeneration, “says Ebra Himi.

This study opens the door to many unanswered questions.For example, various [FeS] Do proteins regulate and regulate immune system responses at the cellular and molecular levels?How viral proteins [FeS] cluster? Further research should be aimed at answering these questions and revealing new insights into host-viral interactions.

The study was published in Nature Chemistry..


Structural insights into Fe-S protein biosynthesis


For more information:
Kourosh Honarmand Ebrahimi et al, iron-sulfur cluster as an inhibitor and catalyst for viral replication, Nature Chemistry (2022). DOI: 10.1038 / s41557-021-00882-0

Quote: Researchers [FeS] Clusters function as biological fusions in many proteins involved in the immune response (February 16, 2022). Obtained February 16, 2022 from https: //phys.org/news/2022-02-fes-clusters-biological-fuses-proteins.html

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Researchers [FeS] Clusters function as biological fusions of many proteins involved in the immune response

Source link Researchers [FeS] Clusters function as biological fusions of many proteins involved in the immune response

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