Researchers shed new light on the molecular mechanisms of brain disease

PET scan of the human brain with Alzheimer’s disease.Credit: public domain

Ratgers researchers have discovered some of the first molecular insights into how toxic proteins are regulated in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.

The study will be displayed in the journal Minutes of the National Academy of Sciences..

Although cells naturally age and die, proper regulation of cellular proteins is important for maintaining a healthy brain with age. In neurodegenerative diseases Protein aggregates-Or an aggregated fragment of a misfolded protein-spreads into adjacent cells, but it is not well understood how the toxic substance migrates.

Researchers at Rutgers have studied roundworms, where stressed nerve cells can extrude neurotoxic proteins in large packets called exothers, and how certain stresses affect this expulsion. They found that certain cellular signals were needed to form the exosofa, and unexpectedly, fasting dramatically increased the production of the exosofa. They also identified three cellular pathways that increase exosofa production during fasting.

“We report molecular insights into the regulation of aggregate metastasis biology related to the fundamental mystery of neurodegenerative diseases in establishing an early molecular model of tissue cross-tissue requirements for fasting-induced ectoderm elevation in neurons.” Said Jason Cooper, the lead author of the study. Postdoctoral Fellow, Department of Molecular Biology and Biochemistry, Rutgers University, New Brunswick.

“In neurodegenerative diseases, toxic proteins spread to adjacent cells and promote cell death. Given the importance of management. protein Aging and aggregate Neurodegenerative diseases And if the biology of how those aggregates are transmitted is not fully understood, a detailed understanding of the transmission mechanism may reveal previously unrecognized therapeutic targets. not. ”

Newly discovered mechanisms for protecting neurons may underlie brain disease

For more information:
Jason F. Cooper et al, Increased stress in neuronal extrusion via exosof requires lipid biosynthesis, FGF, and EGF RAS / MAPK signaling. Proc Natl Acad Sci (2021).

Provided by
Rutgers University

Quote: Researchers of brain disease (September 13, 2021) obtained from https: // on September 13, 2021 Shedding new light on the molecular mechanism

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Researchers shed new light on the molecular mechanisms of brain disease

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