Safely irradiate cancer patients with “FLASH”

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Researchers at the Lawrence Livermore National Laboratory (LLNL) have shown for the first time the potential of a linear guided accelerator (LIA) to irradiate cancer patients with effective, targeted doses of “flash” radiation. The new technology selectively kills cancer cells with minimal damage to healthy cells.An overview of the approach Science report paper.

For decades cancer Treatment often means low-dose radiation for several weeks, hoping to irradiate the malignant cells with a sufficient amount without causing much damage to the patient’s healthy cells. Efforts to provide rapid and high-dose therapeutic radiation or FLASH radiation therapy (FLASH-RT) at the required depth require large and complex machines in the size of gymnasiums and have so far been used clinically. Has proven to be unrealistic.In Science report According to the paper, the authors state that a LIA strong enough to provide the required dose rate to cancer cells can be constructed in a length of only 3 meters.

Developed as part of the institute’s stockpiling management program, the powerful LIA has been used by LLNL in nuclear and stockpiling experiments since the 1960s. Standard RF and microwave accelerators were not powerful enough. Site 300, Nevada National Security Site, and Los Alamos National Laboratory use large versions of these accelerators to emit a flash of radiation, some of which are continuously simulated video of a nuclear implosion, “flip book.” Create a. Both of these uses in LLNL’s weapons program have been supported by laboratory scientist and lead author Stephen Sampayan for their potential use in cancer treatment. Although LIA has been used for decades, he said it was not previously considered for use in clinical applications because the industry is new to LIA and the device can be quite large. ..

“You are spinning off what could be a major breakthrough in cancer radiation therapy, combining technologies developed for weapons that are either diagnostic or weapon design itself,” he said. ..

This paper outlines the situation of LIA technology, The research team’s efforts to stabilize the relevant physics and electron beam. For FLASH-RT, minimum dose rate> 40 Gy s-1 (Measurement of radiation dose applied over a period of time) has previously been shown to be most effective at 100 Gy and above.-1 To ensure a healthy tissue-preserving effect. However, instantaneous dose rates above 2 x 10 are also important.Five Gy-s-1, This is out of the reach of traditional accelerators, Sampayan said. There is increasing evidence that higher instantaneous dose rates are even more effective while keeping the patient’s time below. radiation Make it as low as possible.

Produce a dose that is high enough to kill cancer cells, but short enough to avoid damage to health. cell, The LLNL team has developed an approach that includes LIA to generate four beamlets symmetrically placed around the patient. Controlling the magnets allows researchers to focus on maneuverable FLASH-RT beams that can revolutionize oncology. Further research may show that LIA FLASH-RT in clinical practice is effective not only for centralized cancers such as tumors, but also for decentralized cancers such as brain and blood.

Additional laboratory scientists involved in this paper are George Caporaso, Yu-Jiuan Chen, Steve Falabella, Steven Hawkins, James Watson, Jan-Mark Zentler, and Opcondys Inc. Kristin Sampayan and Jason Hearn from the Department of Radiation Oncology, University of Michigan. ..

Researchers are piloting FLASH radiation therapy beam development for cancer treatment

For more information:
Stephen E. Sampayan et al, Megavolt Bremsstrahlung Measurements from a Linear Induced Accelerator Shows Potential Use as a FLASH Radiation Therapy Source to Reduce Acute Toxicity. Science report (2021). DOI: 10.1038 / s41598-021-95807-9

Quote: Https: // “FLASH” (December 1, 2021) obtained on December 1, 2021 for safe for cancer patients Deliver radiation

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Safely irradiate cancer patients with “FLASH”

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