Scientists have discovered an amazing new way tuberculosis suppresses immunity

Mycobacterium tuberculosisScanning electron micrograph of the fungus. Credit: NIAID “width =” 640 “height =” 530 “/>

Scanning electron micrograph Mycobacterium tuberculosis Bacteria that cause tuberculosis. Credit: NIAID

When a person is infected with Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, the body’s immune response becomes important for the progression of the disease. Helps the body fight bacteria or exacerbates infection.

Researchers at the University of Maryland have discovered how Mtb can cause people Immune cells To lower their defense. Specifically, they identified a bacterial gene that suppresses the immune defenses of infected human cells, which can exacerbate the infection.

This new discovery may indicate an effective target for gene-based treatment or prophylaxis tuberculosisAccording to the World Health Organization, this kills about 10 million people annually and kills 1 million people annually. Only 85% of the treatments available are effective, and multidrug-resistant tuberculosis poses a public health threat in many parts of the world.This study was published in the journal on July 29, 2021. PLOS pathogen..

“Understanding the molecular mechanisms by which bacterial proteins interact with human cells is essential for developing new therapeutic targets,” said a professor of cell biology and molecular genetics at UMD. Said Volker Breaken, the lead author of. “This stimulates the discovery of an unobserved interaction between the tuberculosis-causing bacteria and the signaling system. Human cells It is important in the defense of cells against pathogens. “

Briken and his team, led by fellow postdoctoral fellow and lead author of the study, Sivangi Lastgi, infect a type of white blood cell called a macrophage with either the tuberculosis-causing bacterium Mtb or a non-toxic bacterium. I found it by. Observe the reaction of the cells.Researchers have found that protein complexes Inflammasome It was dramatically restricted in cells infected with Mtb, but not in cells infected with non-pathogenic bacteria.The inflammasome examines the inside of the cell for the pathogen and then signals the cell to launch the pathogen. Immune response

“It was very unexpected for us to find this key observation that Mtb can actually inhibit the inflammasome,” Briken said. “Infection also causes slight activation of the inflammasome, so we don’t have to look for potential process inhibition by Mtb. This is a classic example of a tug of war with a pathogen that wants to suppress the host’s immunity. .. Host cell Detects pathogens and activates immune response. “

Next, the team wanted to know if a particular Mtb gene was involved in the suppression of the inflammasome.Researcher inserted gene Mtb was infected with a non-toxic Mycobacterium species and these mutants were used to infect new macrophages.They found that infection by a non-toxic bacterium carrying the Mtb gene named PknF limits the inflammasome response of host cells.

“We don’t know how this gene inhibits the inflammasome, but probably because the function of this gene is to regulate lipid production and / or secretion, how bacteria affect lipid secretion. I think it will be modified with the inflammasome. That is what we will investigate in future research. “

How PknF Suppresses Host Inflammasome cell It’s just one of the questions Briken wants to answer. He and his team are also working to determine the role of PknF in the pathogenicity of the disease. If suppression of the inflammasome is found to increase the toxicity of Mtb, the PknF gene may be an excellent target for future drug therapies to treat the disease.

Research paper “Mycobacterium tuberculosis inhibits NLRP3 inflammasome activation via its phosphokinase PknF”, Sivangi Lastgi, Sarah Erinwood, Jack Ogenstrich, Katrin D. Mayer Barber, Volker Briken was published on July 29, 2021. PLOS pathogen..

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For more information:
“Mycobacterium tuberculosis inhibits the activation of the NLRP3 inflammasome through its phosphokinase PknF.” PLOS pathogen (2021).… journal.ppat.1009712

Quote: Scientists have discovered a surprising new way tuberculosis suppresses immunity (July 29, 2021). Obtained July 29, 2021 from https: //

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Scientists have discovered an amazing new way tuberculosis suppresses immunity

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