Scientists use gene editing to produce complex antibiotics, fight antimicrobial resistance, treat disrespectful illnesses, and move to future medicines that are urgently needed to tackle future pandemics. I found a new route to reprogram my route.
Researchers at the University of Manchester have discovered new ways to manipulate the major bacterial assembly line enzymes that may pave the way for a new generation of antibiotic treatments.
New research announced today Nature CommunicationsDescribes how to use CRISPR-Cas9 gene editing to create a new nonribosomal peptide synthetase (NRPS) enzyme that delivers clinically important antibiotics. The NRPS enzyme is a rich producer of natural antibiotics such as penicillin. However, until now, manipulating these complex enzymes to produce new and more effective antibiotics has been a major challenge.
The UK government estimates that antimicrobial resistance (AMR) infections cause 700,000 deaths worldwide each year and is projected to cost the global economy $ 100 trillion and reach 10 million by 2050. I am. The AMR also threatens many of the United Nations Sustainable Development Goals (SDGs). ), Additional 28 million people who may be forced Extreme poverty By 2050, unless AMR is included.
Manchester’s team says it could use a gene-editing process to produce improved antibiotics, leading to the development of new therapies to help fight. Drug resistant pathogen And future illness. Jason Micklefield, a professor of chemical biology at the Manchester Institute for Biotechnology (MIB) in the United Kingdom, explains: “The emergence of antibiotic-resistant pathogens is one of the greatest threats we face today.”
“The gene editing approach we have developed is a very efficient and rapid way to design complex assembly line enzymes that can generate new antibiotic structures with potentially improved properties.”
Microorganisms in our environment, such as soil-dwelling bacteria, have evolved the nonribosomal peptide synthetase enzyme (NRPS) that they assemble. Building block Called amino acid Often for peptide products with very strong antibiotic activity. Many of the most therapeutically important antibiotics used in today’s clinics are derived from these NRPS enzymes (penicillin, vancomycin, daptomycin, etc.).
Unfortunately, deadly pathogens that are resistant to all of these existing antibiotics have emerged. One solution is to create new antibiotics with improved properties that can circumvent the pathogen resistance mechanism. However, nonribosomal peptide antibiotics have a very complex structure and are difficult and expensive to produce by conventional chemical methods. To address this, the Manchester team will use gene editing to design NRPS enzymes and exchange domains that recognize different amino acid building blocks, leading to a new assembly line that can offer new peptide products.
Micklefield added: “Gene editing can now be used to introduce targeted changes to complex NRPS enzymes and incorporate alternative amino acid precursors into peptide structures. New approaches provide new ways to improve. I am optimistic that it may be brought about. Antibiotics There is an urgent need to fight new drug-resistant pathogens. “
The research paper is published in Nature Communications “Gene editing enables rapid engineering of complex antibiotic assembly lines.”
Wei Li Thong et al, Gene Editing enables rapid engineering of complex antibiotic assembly lines. Nature Communications (2021). DOI: 10.1038 / s41467-021-27139-1
Quote: Scientists are new antibiotics by genetic editing (November 25, 2021) obtained on November 25, 2021 from https: //phys.org/news/2021-11-scientists-antibiotics-gene.html. Produce material
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Scientists produce new antibiotics by genetic editing
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