Sensitivity to painful external stimuli maintained at all stages of Alzheimer’s disease in mice

Figure 1. Schematic of the sole test of the thermal stimulation protocol used. Sensory discrimination dimension of thermal withdrawal response in normal aging male and female 3xTg-AD and age-matched NTg mice. (A) Infrared light stimulation was applied every 10 minutes under the sole surface of the hind paw (both left and right) and tail of the mouse with an activity intensity of low 20 W and high 40 W. The withdrawal latency of the foot (PWL) and tail (TWL) was recorded in the sensory identification dimension, and the total number of defecations was recorded in the emotional dimension. (B) Hindfoot withdrawal reaction at low intensity 20-W (C) and high intensity 40-W (D). Tail pulling at low strength 20W (E) and high strength 40W. Group: NTg, non-transgenic mouse (white bar); 3xTg-AD, transgenic mouse (male “black”, female “red” bar). Error bars represent the average ± SEM. Statistics: Sexual Impact, S ***, p

The increasing number of very old people, where some pain-related chronic illnesses may converge, is interesting to study the regulatory mechanisms of the central nervous system that can respond to painful external stimuli. I will make it. Problems related to burns may be related to the daily lives of the elderly, but in people with dementia, exposure to high temperatures significantly increases the risk of burns.

UAB researchers investigated the body’s ability to detect pain caused by harmful external stimuli and its susceptibility to this pain in mice with varying levels of cognitive decline caused by Alzheimer’s disease. diseaseBy exposing them to a heat source. In this study, we studied the response of animals from shortly after birth to old age, mimicking the asymptomatic to advanced neuropathological stage. Conducted by Professor Lydia Jimenez Lorto and Dr. Toni Kanjete, researchers from both the Department of Psychiatry and Forensic Medicine and the Institute of Neuroscience (INc) recently published the results of this study in a journal. Frontier of Aging Neuroscience..

This study shows that sensitivity and response to pain are maintained at all stages of the disease. And for the first time, it characterizes age and gender differences in sensory and emotional responses: women are more sensitive to pain, while men are more emotionally affected by it (pain, anxiety, and Fear). The researchers also warned of the need to conduct independent studies in female and male mice, as they detected false-negative results in the “gender and age blindness” analysis.

“Our results, along with other previous results obtained when observing the response to cold stimuli, confirm that nociceptive system susceptibility is also present in the most advanced stages of Alzheimer’s disease. Reveals changes in the phenotype of the disease to which the underlying mechanisms involved should be involved. Study according to age and gender, “points Lydia Jimenez Ryorto. “Furthermore, we will study the behaviors and mechanisms associated with pain responses and possible new treatments in these individuals, supporting similar results from previous studies conducted in patients with dementia. We will validate the mouse model used for this, “she adds.

“This study will also help advance preclinical studies to manage pain in patients with dementia from a gender medical perspective. pain Gender-specific treatments, “says Toni Cañete.

To carry out the study, researchers tested mice in a heat susceptibility test similar to that performed in humans suffering from cognitive decline, with the aim of observing psychobiological responses.

No maiden suffering from pain: women report low pain susceptibility when tested by men

For more information:
Toni Cañete et al, maintained thermal pain in 3xTg-AD mice and increased sensorimetric pain sensitivity in females, but as an early sex-specific AD phenotypic biomarker in males emotional-emotional dimension, Frontier of Aging Neuroscience (2021). DOI: 10.3389 / fnagi.2021.683412

Quote: Sensitivity to painful external stimuli conserved at all stages of Alzheimer’s disease in mice (September 21, 2021) https: // Obtained from stimuli-phases on September 21, 2021. html

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Sensitivity to painful external stimuli maintained at all stages of Alzheimer’s disease in mice

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