(HealthDay)-Six inflammatory proteins are upregulated in plasma years before the diagnosis of ulcerative colitis. Gastroenterology..
Daniel Bergemalm, MD, Ph.D., Orebro University Hospital, Sweden. And a colleague Ulcerative colitis Biobanked plasma samples from 72 individuals who developed ulcerative colitis in later years and 140 consistent healthy controls. 92 proteins associated with inflammation were measured. The biological relevance of the findings was validated in 101 patients with ulcerative colitis and 50 healthy control initiation cohorts.Genetic and Environmental factors These markers were examined in a cohort of 41 healthy twin siblings and 37 matching healthy controls in patients with ulcerative colitis.
Researchers have upregulated six proteins in preclinical ulcerative colitis compared to controls in univariate and multivariate models (MMP10, CXCL9, CCL11, SLAMF1, CXCL11, and MCP-1). I found that. Several potential major regulators, including interleukin-1β, have been identified. Tumor necrosis factor, Interferon-gamma, oncostatin M, nuclear factor-κB, interleukin-6, and interleukin-4. In the initiation cohort, a multivariable model distinguished patients who had not been treated for ulcerative colitis from controls who underwent cross-validation without one (subcurve area, 0.92). Among healthy twin siblings, MMP10, CXCL9, CXCL11, and MCP1 were significantly upregulated rather than CCL11 and SLAMF1, but their relative abundance was accidental ulcerative colitis. Was higher.
“Our findings provide new data on the initial sequence of inflammatory events that ultimately lead to ulcerative colitis, as activation of several proteins was caused by exposure to genetic and environmental risk factors. I will do it, “the author writes.
Some authors are employees of Olink Proteomics.
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Six proteins upregulated years before the diagnosis of ulcerative colitis
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