Smoking directly related to high risk of subarachnoid hemorrhage

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According to a new study published today, adults who smoke or are genetically predisposed to smoking are more likely to experience a serious type of stroke called subarachnoid hemorrhage (SAH). stroke, The journal of the American Heart Association, a division of the American Heart Association. The results of this study provide important evidence that there is a causal link between smoking and the risk of SAH.

SAH is a type of stroke that occurs when blood vessels on the surface of the brain rupture and bleed into the space between the brain and the skull. It mainly affects middle-aged adults and has a high rate of complications and deaths.

“Previous studies have shown that smoking is at increased risk of SAH, but it is unclear whether another confusion state, such as smoking or high blood pressure, is the cause of the stroke,” said the senior author of the study. Guido Falcone, MD says. Sc.D., MPH, Associate Professor of Neurology, Yale University School of Medicine in New Haven, Connecticut. “The definitive causal relationship between smoking and the risk of SAH, like other types of stroke, has not been established so far.”

To determine if there is a causal link between smoking and SAH, researchers analyzed genetic data from 408,609 people aged 40-69 at UK Biobank at the time of recruitment (2006-2010). SAH incidence was collected throughout the study, with a total of 904 SAHs occurring by the end of the study. Researchers have developed a genetic risk scoring system that includes genetic markers associated with smoking risk and tracked smoking behavior data collected when each participant was recruited.

Researchers have discovered it:

  • The relationship between smoking and SAH risk appears to be linear, with a 27% increase in risk for those who smoke half to 20 packs of cigarettes annually.
  • Heavy smokers who smoke more than 40 packs of cigarettes annually were almost three times more at risk of SAH than nonsmokers. And
  • People who were genetically predisposed to smoking behavior had a 63% increased risk of SAH.

“Our results focus on assessing whether we can better identify people at high risk of developing any of these types of cerebral hemorrhage using information about genetic mutations that lead to smoking in the future. Provides the legitimacy of the study, “said neurologist Julian N. Acosta, Doctor of Medicine. , Postdoctoral Fellow and Principal Investigator, Yale University School of Medicine. “These target populations may benefit from aggressive diagnostic interventions that can lead to early detection of aneurysms that cause this serious type of hemorrhagic stroke.”

Researchers believe that their findings suggest more obvious and detrimental effects of smoking in women and adults with hypertension, but larger studies are needed to confirm these results. Say you are. Their analysis is also limited by the type of data used by UK Biobank. This relies on the standardized treatment code of the chart, as well as all large information resources, but small studies have focused on more detailed health records and information for each individual. I will.

Men under 50: The more you smoke, the more strokes you have

For more information:
stroke (2021). DOI: 10.1161 / STROKEAHA.120.031622

Courtesy of the American Heart Association

Quote: Smoking directly related to high risk of subarachnoid hemorrhage (January 14, 2021), https: // 2021 Obtained on January 14th.

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Smoking directly related to high risk of subarachnoid hemorrhage

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