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Stimulant use and intimate violence weaken the immune system of HIV-positive men

HIV-infected H9t cells. Credit: NIAID

A study of HIV-positive black and Latin men having sex with men found that the use of methamphetamine in combination with intimate violence increased the activity of genes that regulate the body’s inflammatory and antiviral functions. understood. This combination can lead to the depletion of the immune system of people living with HIV, increasing the risk of developing chronic illnesses such as cardiovascular disease and other disorders.

Social genomics, Social factors It affects genetic activity and indicates that adverse social adversity such as discrimination and violence is associated with substance abuse and HIV.Researchers in this study found that the use of methamphetamine, unsuppressed viral load, and Intimate violence Inflammation of type I interferon and an increase in type I interferon, which are activities known to promote the depletion of immune cells such as CD4 and CD8, can be predicted. Virus replication..

Researchers recruited 147 HIV-positive black and Latin men to have sex with men from the UCLA Linking Infections Noting Effects (mSTUDY) MSM and substance cohort. mSTUDY examines data from both HIV-positive and HIV-negative Los Angeles County men who have sex with men of predominantly Latin and Black / African-American backgrounds. These communities are imbalanced in the effects of HIV and are considered a high priority by preventive research.

At the molecular level, findings show that both social challenges and substance use play a role in the immune function of people living with HIV. These factors need to be considered together when studying the link between stress and illness, but further research is needed to investigate this over the long term.


Domestic Violence Survivor Risk of Elder Abuse


For more information:
Methamphetamine use, HIV viral load, and social genomics of social adversity, Annual report of behavioral medicine (2021). DOI: 10.1093 / abm / kaab096

Quote: Use of females, intimate violence weakens the immune system of HIV-positive men (December 4, 2021). html

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Stimulant use and intimate violence weaken the immune system of HIV-positive men

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